ArticleNature communications2015
Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection.Nature protocols · 2026Review
- Sex differences inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence that injury can causebioRxiv : the preprint server for biology · 2026Article
- Gene and transposable element expression in response to stress in temperate and tropical populations of Drosophila.Mobile DNA · 2025Article
- Standard ingredient ofMicrobiology spectrum · 2025Article
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- Genetic Variation in Trophic Avoidance Behaviour Shows Fruit Flies are Generally Attracted to Bacterial Substrates.Ecology and evolution · 2024Article
- DGRPool, a web tool leveraging harmonizedeLife · 2024Article
- Alternative splicing perspective to prey preference of environmentally friendly biological agent Cryptolaemus montrouzieri.BMC genomics · 2024Article
- Effects of an entomopathogenic fungus on the reproductive potential ofEcology and evolution · 2024Article
- The genetic basis of variation in immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster.PLoS pathogens · 2023Article
- The Interplay Between Developmental Stage and Environment Underlies the Adaptive Effect of a Natural Transposable Element Insertion.Molecular biology and evolution · 2023Article
- Gene expression differences consistent with water loss reduction underlie desiccation tolerance of natural Drosophila populations.BMC biology · 2023Article
- Neural control of redox response and microbiota-triggered inflammation inFrontiers in immunology · 2023Article
- Genetic covariance in immune measures and pathogen resistance in decorated crickets is sex and pathogen specific.The Journal of animal ecology · 2022Article
- Adaptation to a bacterial pathogen inEcology and evolution · 2022Article
- Article
- The molecular architecture of Drosophila melanogaster defense against Beauveria bassiana explored through evolve and resequence and quantitative trait locus mapping.G3 (Bethesda, Md.) · 2021Article
- Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila.Genome biology · 2021Article
- DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans.Nature communications · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium Pseudomonas entomophila and observe extensive variation in survival. Using genome-wide association analysis, we identify several novel immune modulators. Transcriptional profiling further shows that the intestinal molecular state differs between resistant and susceptible lines, already before infection, with one transcriptional module involving genes linked to reactive oxygen species (ROS) metabolism contributing to this difference. This genetic and molecular variation is physiologically manifested in lower ROS activity, lower susceptibility to ROS-inducing agent, faster pathogen clearance and higher stem cell activity in resistant versus susceptible lines. This study provides novel insights into the determinants underlying population-level variability in gut immunocompetence, revealing how relatively minor, but systematic genetic and transcriptional variation can mediate overt physiological differences that determine enteric infection susceptibility.
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