ArticleJournal of magnetic resonance imaging : JMRI2016
Biomimetic phantom for cardiac diffusion MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Pore size estimation in axon-mimicking microfibers with diffusion-relaxation MRI.Magnetic resonance in medicine · 2024Article
- Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo.Magnetic resonance in medicine · 2023Article
- Validation of cardiac diffusion tensor imaging sequences: A multicentre test-retest phantom study.NMR in biomedicine · 2022Article
- Validating pore size estimates in a complex microfiber environment on a human MRI system.Magnetic resonance in medicine · 2021Article
- Investigation of anisotropic fishing line-based phantom as tool in quality control of diffusion tensor imaging.Radiological physics and technology · 2019Article
- Simulating orientation and polarization characteristics of dense fibrous tissue by electrostatic spinning of polymeric fibers.Biomedical optics express · 2019Article
- Physical and numerical phantoms for the validation of brain microstructural MRI: A cookbook.NeuroImage · 2018Review
- Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging.Materials & design · 2018Article
- Hollow Polycaprolactone Microspheres with/without a Single Surface Hole by Co-Electrospraying.Langmuir : the ACS journal of surfaces and colloids · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeDiffusion magnetic resonance imaging (MRI) is increasingly used to characterize cardiac tissue microstructure, necessitating the use of physiologically relevant phantoms for methods development. Existing phantoms are generally simplistic and mostly simulate diffusion in the brain. Thus, there is a need for phantoms mimicking diffusion in cardiac tissue. MATERIALS AND
methodsA biomimetic phantom composed of hollow microfibers generated using co-electrospinning was developed to mimic myocardial diffusion properties and fiber and sheet orientations. Diffusion tensor imaging was carried out at monthly intervals over 4 months at 9.4T. 3D fiber tracking was performed using the phantom and compared with fiber tracking in an ex vivo rat heart.
resultsThe mean apparent diffusion coefficient and fractional anisotropy of the phantom remained stable over the 4-month period, with mean values of 7.53 ± 0.16 × 10(-4) mm(2) /s and 0.388 ± 0.007, respectively. Fiber tracking of the 1st and 3rd eigenvectors generated analogous results to the fiber and sheet-normal direction respectively, found in the left ventricular myocardium.
conclusionA biomimetic phantom simulating diffusion in the heart was designed and built. This could aid development and validation of novel diffusion MRI methods for investigating cardiac microstructure, decrease the number of animals and patients needed for methods development, and improve quality control in longitudinal and multicenter cardiac diffusion MRI studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.