Evidence map›Paper›PMID 26212684›Full record

ReviewNeurotoxicology and teratology

Developmental and behavioral consequences of prenatal methamphetamine exposure: A review of the Infant Development, Environment, and Lifestyle (IDEAL) study.

Lynne M Smith, Sabrina Diaz, Linda L LaGasse, Trecia Wouldes, Chris Derauf, Elana Newman, Amelia Arria, Marilyn A Huestis, William Haning, Arthur Strauss and 4 more

Abstract readReview
In one paragraph

Review in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Mechanisms underlying methamphetamine-induced disruption of testicular integrity.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  2. Methamphetamine use in pregnancy: avenues for future research.American journal of obstetrics and gynecology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Prenatal Substance Exposure.Annual review of developmental psychology · 2023
    Article
  7. Maternal use of methamphetamine alters cardiovascular function in the adult offspring.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2023
    Review
  8. Review
  9. The tragedy of smoking, alcohol, and multiple substance use during pregnancy.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2022
    Article
  10. Methamphetamine: burden, mechanism and impact on pregnancy, the fetus, and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Review
  11. An environmental scan of impacts and interventions for women with methamphetamine use in pregnancy and their children.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lynne M SmithDepartment of Pediatrics, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: smith@labiomed.org.
Sabrina DiazDepartment of Pediatrics, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Linda L LaGassePediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.
Trecia WouldesDepartment of Psychological Medicine, University of Auckland, New Zealand.
Chris DeraufDepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Elana NewmanDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Amelia ArriaFamily Science Department, Center on Young Adult Health and Development, University of Maryland School of Public Health, College Park, MD, USA.
Marilyn A HuestisIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
William HaningDepartment of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Arthur StraussMiller Children's Hospital Long Beach (MCHLB), Long Beach, CA, USA.
Sheri Della GrottaPediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.
Lynne M DansereauPediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.
Charles NealDepartment of Psychological Medicine, University of Auckland, New Zealand.
Barry M LesterPediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
WILLINGNESS OF PRIMARY CARE PHYSICIANS TO ADOPT HANDHELD COMPUTINGP20RR011091 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI ERDEM, GULIZ · 1995 to 2009
$16.5M
Prental Methamphetamine Exposure and Child DevelopmentR01DA014948 · NIDA · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M. · 2001 to 2013
$14.5M
Monitoring In Utero Drug ExposureZIADA000433 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SCHEIDWEILER, KARL · 2009 to 2016
$2.9M
NCATS NIH HHS 1UL1-TR000124NCATS NIH HHS UL1 TR000124NCRR NIH HHS 5P20 RR11091NCRR NIH HHS P20 RR011091NIDA NIH HHS 1R01DA014948NIDA NIH HHS R01 DA014948
6 · The paper itself

Abstract

This study reviews the findings from the Infant Development, Environment, and Lifestyle (IDEAL) study, a multisite, longitudinal, prospective study designed to determine maternal outcome and child growth and developmental findings following prenatal methamphetamine exposure from birth up to age 7.5 years. These findings are presented in the context of the home environment and caregiver characteristics to determine how the drug and the environment interact to affect the outcome of these children. No neonatal abstinence syndrome requiring pharmacologic intervention was observed but heavy drug exposure was associated with increased stress responses in the neonatal period. Poorer inhibitory control was also observed in heavy methamphetamine exposed children placing them at high risk for impaired executive function. Independent of methamphetamine exposure, children with more responsive home environments to developmental and emotional needs demonstrated lower risks for internalizing and externalizing behavior.

Indexed as

Life StylePrenatal Exposure Delayed EffectsAnimalsCentral Nervous System StimulantsDevelopmental DisabilitiesFemaleHumansInfantMethamphetaminePregnancyCentral Nervous System StimulantsMethamphetamineLongitudinalMethamphetamineNeurodevelopmentPrenatal exposure

Identifiers

PMID26212684
PMCPMC4668928

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.