Evidence map›Paper›PMID 26212613›Full record

ArticleNature communications2015

Evolution of dosage compensation under sexual selection differs between X and Z chromosomes.

Charles Mullon, Alison E Wright, Max Reuter, Andrew Pomiankowski, Judith E Mank

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
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  5. Sharks and rays have the oldest vertebrate sex chromosome with unique sex determination mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Dosage compensation evolution in plants: theories, controversies and mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  16. Review
  17. Review
  18. Do male and female heterogamety really differ in expression regulation? Lack of global dosage balance in pygopodid geckos.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  19. Thermosensitive sex chromosome dosage compensation in ZZ/ZW softshell turtles,Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  20. Expanding the classical paradigm: what we have learnt from vertebrates about sex chromosome evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charles Mullon1] Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK [2] CoMPLEX, University College London, Gower Street, London WC1E 6BT, UK [3] Department of Ecology and Evolution, Biophore, University of Lausanne, Ch-1015 Lausanne, Switzerland.
Alison E Wright1] Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK [2] Department of Zoology, University of Oxford, The Tinbergen Building, South Parks Road, Oxford OX1 3PS, UK.
Max ReuterDepartment of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.ORCID 0000000195540795
Andrew Pomiankowski1] Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK [2] CoMPLEX, University College London, Gower Street, London WC1E 6BT, UK.
Judith E MankDepartment of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete sex chromosome dosage compensation has more often been observed in XY than ZW species. In this study, using a population genetic model and the chicken transcriptome, we assess whether sexual conflict can account for this difference. Sexual conflict over expression is inevitable when mutation effects are correlated across the sexes, as compensatory mutations in the heterogametic sex lead to hyperexpression in the homogametic sex. Coupled with stronger selection and greater reproductive variance in males, this results in slower and less complete evolution of Z compared with X dosage compensation. Using expression variance as a measure of selection strength, we find that, as predicted by the model, dosage compensation in the chicken is most pronounced in genes that are under strong selection biased towards females. Our study explains the pattern of weak dosage compensation in ZW systems, and suggests that sexual selection plays a major role in shaping sex chromosome dosage compensation.

Indexed as

Evolution, MolecularGene ExpressionAnimalsChickensDosage Compensation, GeneticFemaleGene Expression ProfilingMaleSelection, GeneticSex ChromosomesX ChromosomeX Chromosome Inactivation

Identifiers

PMID26212613
PMCPMC4525201

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.