Evidence map›Paper›PMID 26212464›Full record

Trial reportArthritis care & research2015

Multidimensional Model of Disability and Role Functioning in Rheumatoid Arthritis.

Sarah R Ormseth, Taylor L Draper, Michael R Irwin, Michael H Weisman, Adam E Aréchiga, Narineh Hartoonian, Thuy Bui, Perry M Nicassio

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis care & research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah R OrmsethCousins Center for Psychoneuroimmunology, David Geffen School of Medicine, University of California, Los Angeles.
Taylor L DraperLoma Linda University, Loma Linda, California.
Michael R IrwinCousins Center for Psychoneuroimmunology, David Geffen School of Medicine, University of California, Los Angeles.
Michael H WeismanCedars Sinai Medical Center, Los Angeles, California.
Adam E AréchigaLoma Linda University, Loma Linda, California.
Narineh HartoonianUniversity of Washington School of Medicine, Seattle.
Thuy BuiCalifornia School of Professional Psychology of Alliant International University, Alhambra.
Perry M NicassioCousins Center for Psychoneuroimmunology, David Geffen School of Medicine, University of California, Los Angeles.

Funding

UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Chronic Moderate Sleep Restriction in Older Long and Older Average SleepersR01HL095799 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI IRWIN, MICHAEL R, JEAN-LOUIS, GIRARDIN · 2011 to 2015
$3.8M
Sleep and Immune Mechanisms in Rheumatoid ArthritisR01HL079955 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2009
$3.0M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Behavioral Treatments for Rheumatoid ArthritisR01AR049840 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NICASSIO, PERRY MICHAEL · 2003 to 2007
$1.7M
NCI NIH HHS R01 CA119159NCI NIH HHS R01-CA-119159NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL-RR-033176NHLBI NIH HHS HL-R0-079955NHLBI NIH HHS R01 HL079955NHLBI NIH HHS R01 HL095799NHLBI NIH HHS R01-HL-095799NIAMS NIH HHS AR-R01-049840NIAMS NIH HHS R01 AR049840NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG-028748NIA NIH HHS R01 AG026364NIA NIH HHS R01-AG-026364NIA NIH HHS R01 AG034588NIA NIH HHS R01-AG-034588
6 · The paper itself

Abstract

objectiveTo examine a model addressing the roles of rheumatoid arthritis (RA) disease burden, mood disturbance, and disability as determinants of impairments in role functioning.

methodsIn a cross-sectional design, 103 RA patients recruited from the community to participate in a clinical trial completed assessments of self-assessed disease burden (total joint pain and disease activity), mood disturbance (Center for Epidemiological Studies Depression Scale depressed mood, somatic symptoms, lack of positive affect, and interpersonal problems), disability (Health Assessment Questionnaire disability index gross and fine motor), and role functioning (Short Form 36 health survey physical and social). Structural equation modeling (SEM) was used to examine direct and indirect mechanisms linking disease burden to role functioning.

resultsSEM results indicated that the model had excellent fit: S-Bχ(2)(30) = 38.59, P = 0.135; comparative fit index = 0.977, standardized root mean residual = 0.062, and root mean square error of approximation = 0.053. Mediational analyses demonstrated that, while disease burden was associated with poor role functioning, its effects were jointly mediated by mood disturbance and disability. After the effects of mood disturbance and disability were taken into account, the effect of disease burden on role functioning was not significant.

conclusionThe results indicate that mood disturbance and disability may serve as important pathways through which RA disease burden affects role functioning. Future longitudinal research is suggested to replicate these findings and further explore the mediational mechanisms examined in this study.

Indexed as

Disability EvaluationHealth StatusModels, TheoreticalPain MeasurementSurveys and QuestionnairesAdultAffectAgedArthralgiaArthritis, RheumatoidCost of IllnessCross-Sectional StudiesFemaleHumansMaleMiddle Aged

Identifiers

PMID26212464
PMCPMC4715712

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.