ArticleAmerican journal of surgery2015
Heart rate variability analysis is more sensitive at identifying neonatal sepsis than conventional vital signs.
Article in American journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review.Neonatology · 2023Pooled it
- Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review.BMC pediatrics · 2019Pooled it
- Fetal and Neonatal Heart Rate Trends in Preterm Delivery: A Clinical Study from the Week before to the Week after Birth.American journal of perinatology · 2026Article
- Baseline NIPEEuropean journal of pediatrics · 2025Observational
- Lipopolysaccharide induced systemic inflammation and heart rate variability in a term newborn piglet model.Pediatric research · 2025Article
- The impact of healthy pregnancy on features of heart rate variability and pulse wave morphology derived from wrist-worn photoplethysmography.Scientific reports · 2023Article
- Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway.Signal transduction and targeted therapy · 2022Article
- Feeding intolerance.Early human development · 2022Article
- Heart rate variability in children: methodological issues and clinical applications.Archivos de cardiologia de Mexico · 2022Article
- Autonomic development in preterm infants is associated with morbidity of prematurity.Pediatric research · 2022Article
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Cerebral oxygenation in preterm infants during maternal singing combined with skin-to-skin care.Pediatric research · 2021Observational
- Non-contact heart rate variability monitoring using Doppler radars located beneath bed mattress: a case report.European heart journal. Case reports · 2021Article
- Physiological Sympathetic Activation Reduces Systemic Inflammation: Role of Baroreflex and Chemoreflex.Frontiers in immunology · 2021Article
- Article
- A narrative review of heart rate and variability in sepsis.Annals of translational medicine · 2020Review
- Non-invasive Cardiac Output Monitoring in Neonates.Frontiers in pediatrics · 2020Review
- Cardiorespiratory Alterations in a Newborn Ovine Model of Systemic Inflammation Induced by Lipopolysaccharide Injection.Frontiers in physiology · 2020Article
- Evaluation of the autonomic nervous system by analysis of heart rate variability in the preterm infants.BMC cardiovascular disorders · 2019Observational
- Continuous pulse oximetry and respiratory rate trends predict short-term respiratory and growth outcomes in premature infants.Pediatric research · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundSepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups.
methodsWith Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain.
resultsHRV measurements in time domain, heart rate, and pulse oximetry (SpO2) were significantly different in septic patients vs nonseptic controls.
conclusionsThese results indicate that nonconventional vital signs such as HRV are more sensitive than traditionally used vital signs, such as cardiac output and mean arterial pressure, in the confirmation of sepsis in extremely low birth weight neonates. HRV may allow for earlier identification of septic physiology.
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