ArticleCognition & emotion2016
Cognitive flexibility mediates the relation between intolerance of uncertainty and safety signal responding in those with panic disorder.
Article in Cognition & emotion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Examining the predictive effect of physical activity, daily step count and perceived stress level on cognitive flexibility.Scientific reports · 2025Article
- Characterization and factors influencing the uncertainty of intolerable in older adults with multimorbidity: A Cross-sectional study.BMC geriatrics · 2025Article
- Impact of Intolerance of Uncertainty on Brain Structural Changes in Panic Disorder.Psychiatry investigation · 2023Article
- Intolerance of Uncertainty and Health-Related Anxiety in Youth amid the COVID-19 Pandemic: Understanding and Weathering the Continuing Storm.Journal of clinical psychology in medical settings · 2022Review
- The Chain Mediating Effect of Negative Perfectionism on Procrastination: An Ego Depletion Perspective.International journal of environmental research and public health · 2022Article
- Event-related potentials to acoustic startle probes during unpredictable threat are associated with individual differences in intolerance of uncertainty.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Does cognitive flexibility change the nature of the relationship between intolerance of uncertainty and psychological symptoms during the COVID-19 outbreak in Turkey?Current psychology (New Brunswick, N.J.) · 2022Article
- Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Heightened Defensive Responses Following Subtotal Lesions of Macaque Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Augmentation of Extinction and Inhibitory Learning in Anxiety and Trauma-Related Disorders.Annual review of clinical psychology · 2019Review
- Distinct responses to predictable and unpredictable threat in anxiety pathologies: effect of panic attack.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia.NeuroImage. Clinical · 2017Article
- Is Past Adjustment of Unhelpful Thinking Associated with Greater Cognitive Flexibility Among People Seeking Musculoskeletal Specialty Care?Chronic stress (Thousand Oaks, Calif.)Article
- Transdiagnostic physiological correlates of unpredictable threat anticipation.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is a growing literature associating anxiety disorders with an inability to inhibit defensive responding during safety conditions of threatening tasks. However, investigations on the relation between panic disorder (PD) and defensive responding to safety have yielded mixed results. A recent study from our laboratory revealed that intolerance of uncertainty (IU) moderates this association, such that only individuals with PD and a high IU exhibit heightened startle potentiation during safety. The mechanism underlying this relationship is unknown. Given that safety conditions typically alternate with periods of threat, cognitive flexibility (i.e., the ability to adjust one's habitual responding to a situation, given the input of new information) may be involved in the ongoing reappraisal of danger and adjustment of defensive responding. Thus, the present study sought to investigate whether deficits in cognitive flexibility mediate the association between IU and defensive responding to safety among a sample of 71 adults diagnosed with PD. As hypothesised, cognitive flexibility mediated the relationship between IU and heightened startle potentiation during safety conditions. This finding suggests that within this subgroup, a failure to inhibit defensive responding during safety conditions may be due to deficits in cognitive flexibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.