Evidence map›Paper›PMID 26211738›Full record

ArticleScientific reports2015

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells.

Huanyu Xu, Sen Guo, Wei Li, Ping Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 304 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
304citing papers in PubMed, 3 pooled it
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

304 citing papers in PubMed, 3 syntheses or guidelines pooled it, 549 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. The history and function of a circular RNA.Nature communications · 2026
    Review
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  17. Challenges and Future Prospectives in Circular RNA Investigation.Advances in experimental medicine and biology · 2025
    Review
  18. Review
  19. Article
  20. Role of circular RNAs in preeclampsia (Review).Experimental and therapeutic medicine · 2024
    Review

244 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Huanyu XuInstitute of Genomic Medicine, Wenzhou Medical University, Zhejiang, China.
Sen GuoInstitute of Genomic Medicine, Wenzhou Medical University, Zhejiang, China.
Wei LiZhejiang Provincial Key Laboratory of Medical Genetics; School of Laboratory Medicine &Life Sciences, Wenzhou Medical University, Zhejiang, China.
Ping YuInstitute of Genomic Medicine, Wenzhou Medical University, Zhejiang, China.
Wenzhou Medical University · CNLaboratoire de Génétique Médicale

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the identified thousands of circular RNAs (circRNA) in humans and animals, Cdr1as (also known as CiRS-7) was recently demonstrated to act as a powerful miR-7 sponge/inhibitor in developing midbrain of zebrafish, suggesting a novel mechanism for regulating microRNA functions. MiR-7 is abundantly expressed in islet cells, but overexpressing miR-7 in transgenic mouse β cells causes diabetes. Therefore, we infer that Cdr1as expression may inhibit miR-7 function in islet cells, which in turn improves insulin secretion. Here, we show the first characterization of Cdr1as expression in islet cells, which was upregulated by long-term forskolin and PMA stimulation, but not high glucose, indicating the involvement of cAMP and PKC pathways. Remarkably, both insulin content and secretion were significantly increased by overexpression of Cdr1as in islet cells. We further identified a new target Myrip in the Cdr1as/miR-7 pathway that regulates insulin granule secretion, and also another target Pax6 that enhances insulin transcription. Taken together, our findings revealed the effects of the strongly interacting pair of Cdr1as/miR-7 on insulin secretion, which may become a new target for improving β cell function in diabetes.

Indexed as

AnimalsCell LineGene Expression RegulationInsulinInsulin SecretionIslets of LangerhansMiceMicroRNAsRNARNA, CircularTranscription, GeneticInsulinMicroRNAsMIRN7 microRNA, mouseRNARNA, Circular

Identifiers

PMID26211738
PMCPMC4515639
OpenAlexW1032731786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.