ArticleMolecular ecology2016
On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity.
Article in Molecular ecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Developing an appropriate evolutionary baseline model for the study of SARS-CoV-2 patient samples.PLoS pathogens · 2023Review
- Human herpesvirus diversity is altered in HLA class I binding peptides.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Inferring the distribution of fitness effects in patient-sampled and experimental virus populations: two case studies.Heredity · 2022Article
- Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity.Viruses · 2021Review
- A consideration of within-host human cytomegalovirus genetic variation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection.BMC infectious diseases · 2019Article
- Review
- Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population.mSphere · 2019Article
- HCMV Envelope Glycoprotein Diversity Demystified.Frontiers in microbiology · 2019Article
- Influence of sphingosine-1-phosphate signaling on HCMV replication in human embryonal lung fibroblasts.Medical microbiology and immunology · 2018Article
- The Human Cytomegalovirus Strain DB Activates Oncogenic Pathways in Mammary Epithelial Cells.EBioMedicine · 2018Article
- On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts.Pathogens (Basel, Switzerland) · 2018Review
- Impacts of Genome-Wide Analyses on Our Understanding of Human Herpesvirus Diversity and Evolution.Journal of virology · 2018Review
- Deep Lessons From the Uncultured.The Journal of infectious diseases · 2017Article
- On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations.Journal of virology · 2017Article
- On the importance of skewed offspring distributions and background selection in virus population genetics.Heredity · 2016Review
- The Impact of Linked Selection in Chimpanzees: A Comparative Study.Genome biology and evolution · 2016Article
- Finding the Genomic Basis of Local Adaptation: Pitfalls, Practical Solutions, and Future Directions.The American naturalist · 2016Review
- Refining the Use of Linkage Disequilibrium as a Robust Signature of Selective Sweeps.Genetics · 2016Article
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Authors and funding
3 authors.
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Abstract
A central focus of population genetics has been examining the contribution of selective and neutral processes in shaping patterns of intraspecies diversity. In terms of selection specifically, surveys of higher organisms have shown considerable variation in the relative contributions of background selection and genetic hitchhiking in shaping the distribution of polymorphisms, although these analyses have rarely been extended to bacteria and viruses. Here, we study the evolution of a ubiquitous, viral pathogen, human cytomegalovirus (HCMV), by analysing the relationship among intraspecies diversity, interspecies divergence and rates of recombination. We show that there is a strong correlation between diversity and divergence, consistent with expectations of neutral evolution. However, after correcting for divergence, there remains a significant correlation between intraspecies diversity and recombination rates, with additional analyses suggesting that this correlation is largely due to the effects of background selection. In addition, a small number of loci, centred on long noncoding RNAs, also show evidence of selective sweeps. These data suggest that HCMV evolution is dominated by neutral mechanisms as well as background selection, expanding our understanding of linked selection to a novel class of organisms.
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