Evidence map›Paper›PMID 26210747›Full record

ReviewCurrent opinion in microbiology2015

The parasexual lifestyle of Candida albicans.

Richard J Bennett

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Host skin lipids triggerbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  5. Review
  6. Frequent horizontal chromosome transfer between asexual fungal insect pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Genetic Diversity of Human Fungal Pathogens.Current clinical microbiology reports · 2023
    Article
  8. Article
  9. Article
  10. Microevolution ofeLife · 2022
    Article
  11. Filament Negative RegulatorJournal of fungi (Basel, Switzerland) · 2022
    Article
  12. CRISPR-Mediated Genome Editing in the Human Fungal Pathogen C. albicans.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Richard J BennettDepartment of Molecular Microbiology and Immunology, Brown University, 171 Meeting St, Providence, RI 02912, United States. Electronic address: Richard_Bennett@brown.edu.

Funding

Transcriptional Regulation of C. albicans Cell Fate and Host InteractionsR01AI081704 · NIAID · BROWN UNIVERSITY · PI Richard John Bennett · 2010 to 2026
$6.4M
Phenotypic Switching in Candida albicans and its Role in PathogenesisR21AI081560 · NIAID · BROWN UNIVERSITY · PI BENNETT, RICHARD JOHN · 2009 to 2010
$442k
NIAID NIH HHS R01 AI081704NIAID NIH HHS R01AI081704NIAID NIH HHS R21 AI081560NIAID NIH HHS R21AI081560
6 · The paper itself

Abstract

Candida albicans is both a prevalent human commensal and the most commonly encountered human fungal pathogen. This lifestyle is dependent on the ability of the fungus to undergo rapid genetic and epigenetic changes, often in response to specific environmental cues. A parasexual cycle in C. albicans has been defined that includes several unique properties when compared to the related model yeast, Saccharomyces cerevisiae. Novel features include strict regulation of mating via a phenotypic switch, enhanced conjugation within a sexual biofilm, and a program of concerted chromosome loss in place of a conventional meiosis. It is expected that several of these adaptations co-evolved with the ability of C. albicans to colonize the mammalian host.

Indexed as

Conjugation, GeneticBiofilmsCandida albicansCell DivisionChromosomes, FungalFungal ProteinsGene Expression Regulation, FungalGenes, Mating Type, FungalHumansMeiosisPhenotypePheromonesSaccharomyces cerevisiaeSignal TransductionFungal ProteinsPheromones

Identifiers

PMID26210747
PMCPMC4688137

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.