Evidence map›Paper›PMID 26210741›Full record

ArticleCarcinogenesis2015

PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome.

Alan Fu, Daniel I Jacobs, Aaron E Hoffman, Tongzhang Zheng, Yong Zhu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 153 citations in OpenAlex.

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  13. Non-Coding RNAs in Breast Cancer: Diagnostic and Therapeutic Implications.International journal of molecular sciences · 2024
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alan FuDepartment of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT 06520, USA and Present Address: Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA.
Daniel I JacobsDepartment of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT 06520, USA and.
Aaron E HoffmanDepartment of Epidemiology, Tulane School of Public Health and Tropical Medicine and Tulane Cancer Center, New Orleans, LA 70112, USA.
Tongzhang ZhengDepartment of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT 06520, USA and.
Yong ZhuDepartment of Environmental Health Sciences, Yale University School of Public Health, New Haven, CT 06520, USA and yong.zhu@yale.edu.
Yale University · USTulane University · US

Funding

Yale/NCI Cooperative Training Program in Cancer EpidemiologyT32CA105666 · NCI · YALE UNIVERSITY · PI MA, XIAOMEI · 2008 to 2012
$603k
NCI NIH HHS T32 CA105666
6 · The paper itself

Abstract

Although PIWI-interacting RNAs (piRNAs) account for the largest class of the small non-coding RNA superfamily, virtually nothing is known of their function in human carcinogenesis. Once thought to be expressed solely in the germ line where they safeguard the genome against transposon-induced insertional mutations, piRNAs are now believed to play an active role in somatic gene regulation through sequence-specific histone modification and DNA methylation. In the current study, we investigate the role of piRNA-021285 (piR-021285) in the regulation of the breast cancer methylome. Genotypic screening of a panel of single-nucleotide polymorphism (SNP)-containing piRNAs revealed a significant association between SNP rs1326306 G>T in piR-021285 and increased likelihood for breast cancer in a Connecticut-based population (441 cases and 479 controls). Given nascent but compelling evidence of piRNA-mediated gene-specific methylation in the soma, a genome-wide methylation screen was then carried out using wild type (WT) and variant piR-021285 mimic-transfected MCF7 cells to explore whether the observed association could be attributed in part to piR-021285-induced methylation at cancer-relevant genes. We found significant methylation differences at a number of experimentally implicated breast cancer-related genes, including attenuated 5' untranslated region (UTR)/first exon methylation at the proinvasive ARHGAP11A gene in variant mimic-transfected cells. Follow-up functional analyses revealed both concurrent increased ARHGAP11A mRNA expression and enhanced invasiveness in variant versus WT piR-021285 mimic-transfected breast cancer cell lines. Taken together, our findings demonstrate the first evidence supporting a role of piRNAs, a novel group of non-coding RNA, in human tumorigenesis via a piRNA-mediated epigenetic mechanism, which warrants further confirmation and investigation.

Indexed as

CarcinogenesisBreast NeoplasmsDNA MethylationEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticGTPase-Activating ProteinsHumansNeoplasm InvasivenessPolymorphism, Single NucleotideRNA, Small InterferingRNA, Small UntranslatedARHGAP11A protein, humanGTPase-Activating ProteinsRNA, Small InterferingRNA, Small Untranslated

Identifiers

PMID26210741
PMCPMC5006152
OpenAlexW2125523389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.