ReviewJournal of the American Academy of Child and Adolescent Psychiatry2015
The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children.
Review in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Temperament Characteristics of Children in Residential Care and Perceived Acceptance/Rejection and Style of Discipline Used by Care Workers.Behavioral sciences (Basel, Switzerland) · 2024Article
- Hard-to-treat or hard-to-catch? Clinical features and therapeutic outcomes of help-seeking foster care youths with mood disorders.Frontiers in psychiatry · 2023Article
- The Child PTSD Symptom Scale: Psychometric Properties among Earthquake Survivors.Child psychiatry and human development · 2021Article
- Developmental Consequences of Early Life Stress on Risk for Psychopathology: Longitudinal Associations with Children's Multisystem Physiological Regulation and Executive Functioning.Development and psychopathology · 2021Article
- Early Life Stress and the Fate of Kynurenine Pathway Metabolites.Frontiers in human neuroscience · 2021Article
- A multi-method and multi-informant approach to assessing post-traumatic stress disorder (PTSD) in children.International review of psychiatry (Abingdon, England) · 2020Article
- Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- The Impact of Translational Neuroscience on Revisiting Psychiatric Diagnosis: State of the Art and Conceptual Analysis.Balkan medical journal · 2017Review
- An Integrated Neuroscience Perspective on Formulation and Treatment Planning for Posttraumatic Stress Disorder: An Educational Review.JAMA psychiatry · 2017Review
- Computational Nosology and Precision Psychiatry.Computational psychiatry (Cambridge, Mass.) · 2017Article
- Neuroscience-informed psychoeducation for addiction medicine: A neurocognitive perspective.Progress in brain research · 2017Review
- RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Community pharmacists' recommendations for natural products for stress in Melbourne, Australia: a simulated patient study.Pharmacy practiceArticle
- Developmental Psychopathology and the Research Domain Criteria: Friend or Foe?Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe Research Domain Criteria (RDoC) project was initiated to develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures. This article reviews the rationale behind the RDoC program, its goals, and central tenets; discusses application of an RDoC framework to research with maltreated children; and highlights some clinical implications of this work.
methodPublished RDoC papers were reviewed, together with relevant preclinical and clinical studies that guide our work on risk and resilience in maltreated children.
resultsThe ultimate long-term goal of the RDoC initiative is precision medicine in psychiatry. In the interim, the RDoC initiative provides a framework to organize research to help develop the database required to derive a new psychiatric nomenclature that can appropriately match treatments to patients. The primary focus of RDoC is on neural circuitry, with levels of analyses that span from molecules to behavior. There has been some concern that the RDoC framework is reductionist, with an overemphasis on neural circuits and genetics; however, the briefly reviewed, burgeoning literature on neuroplasticity and epigenetics highlights that this concern is unwarranted, as one cannot study neural circuits and genetics without considering experience.
conclusionThe study of maltreated children has a number of advantages for the RDoC project, including the following: study of a subset of patients who are often not responsive to standard interventions; examination of a relatively homogenous sample with onset of psychopathology proposed to be associated with stress-related mechanisms; and well-established, relevant animal models to facilitate translational research.
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