Evidence map›Paper›PMID 26210175›Full record

ArticleBiomaterials2015

Effect of UV-photofunctionalization on oral bacterial attachment and biofilm formation to titanium implant material.

Erica Dorigatti de Avila, Bruno P Lima, Takeo Sekiya, Yasuyoshi Torii, Takahiro Ogawa, Wenyuan Shi, Renate Lux

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.Frontiers in cellular and infection microbiology · 2021
    Pooled it
  3. Trial
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  8. Article
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  10. Article
  11. Response of Human Gingival Fibroblasts andJournal of functional biomaterials · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Erica Dorigatti de AvilaDivision of Oral Biology and Medicine, University of California - School of Dentistry, Los Angeles, CA, USA; Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Univ Estadual Paulista - UNESP, Araraquara, SP, Brazil.
Bruno P LimaDivision of Oral Biology and Medicine, University of California - School of Dentistry, Los Angeles, CA, USA.
Takeo SekiyaDivision of Advanced Prosthodontics and Weintraub Center for Reconstructive Biotechnology, University of California - School of Dentistry, Los Angeles, CA, USA.
Yasuyoshi ToriiDivision of Advanced Prosthodontics and Weintraub Center for Reconstructive Biotechnology, University of California - School of Dentistry, Los Angeles, CA, USA.
Takahiro OgawaDivision of Advanced Prosthodontics and Weintraub Center for Reconstructive Biotechnology, University of California - School of Dentistry, Los Angeles, CA, USA.
Wenyuan ShiDivision of Oral Biology and Medicine, University of California - School of Dentistry, Los Angeles, CA, USA.
Renate LuxDivision of Oral Biology and Medicine, University of California - School of Dentistry, Los Angeles, CA, USA; Division of Constitutive and Regenerative Sciences, University of California - School of Dentistry, Los Angeles, CA, USA. Electronic address: rlux@dentistry.ucla.edu.
University of California, Los Angeles · US

Funding

Making a quantum leap in plaque research with modern sciencesR01DE020102 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2010 to 2020
$3.7M
Molecular analysis of F. nucleatum interspecies interactions in biofilmsR01DE021108 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUX, RENATE, SHI, WENYUAN · 2011 to 2015
$2.0M
NIDCR NIH HHS DE020102NIDCR NIH HHS DE021108NIDCR NIH HHS R01 DE020102NIDCR NIH HHS R01 DE021108
6 · The paper itself

Abstract

Bacterial biofilm infections remain prevalent reasons for implant failure. Dental implant placement occurs in the oral environment, which harbors a plethora of biofilm-forming bacteria. Due to its trans-mucosal placement, part of the implant structure is exposed to oral cavity and there is no effective measure to prevent bacterial attachment to implant materials. Here, we demonstrated that UV treatment of titanium immediately prior to use (photofunctionalization) affects the ability of human polymicrobial oral biofilm communities to colonize in the presence of salivary and blood components. UV-treatment of machined titanium transformed the surface from hydrophobic to superhydrophilic. UV-treated surfaces exhibited a significant reduction in bacterial attachment as well as subsequent biofilm formation compared to untreated ones, even though overall bacterial viability was not affected. The function of reducing bacterial colonization was maintained on UV-treated titanium that had been stored in a liquid environment before use. Denaturing gradient gel-electrophoresis (DGGE) and DNA sequencing analyses revealed that while bacterial community profiles appeared different between UV-treated and untreated titanium in the initial attachment phase, this difference vanished as biofilm formation progressed. Our findings confirm that UV-photofunctionalization of titanium has a strong potential to improve outcome of implant placement by creating and maintaining antimicrobial surfaces.

Indexed as

Ultraviolet RaysBacterial AdhesionBiofilmsDenaturing Gradient Gel ElectrophoresisDental ImplantsHumansHydrophobic and Hydrophilic InteractionsMouthSurface PropertiesTitaniumDental ImplantsTitaniumBacteriaBiofilmPeri-implantitisPhotofunctionalizationTitanium

Identifiers

PMID26210175
PMCPMC4667792
OpenAlexW872546211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.