Evidence map›Paper›PMID 26210101›Full record

ArticleJournal of colloid and interface science2015

Modification of fluorous substrates with oligo(ethylene glycol) via "click" chemistry for long-term resistance of cell adhesion.

Rafael Contreras-Caceres, Catherine M Santos, Siheng Li, Amit Kumar, Zhiling Zhu, Satya S Kolar, Miguel A Casado-Rodriguez, Yongkai Huang, Alison McDermott, Juan Manuel Lopez-Romero and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of colloid and interface science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Rafael Contreras-CaceresDepartment of Chemistry, University of Houston, Houston, TX 77204, USA; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Málaga, 29071, Spain. Electronic address: rcontreras@uma.es.
Catherine M SantosDepartment of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address: cmsantos@central.uh.edu.
Siheng LiDepartment of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address: sihengli9@gmail.com.
Amit KumarDepartment of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address: aks208@yahoo.com.
Zhiling ZhuDepartment of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address: jeremial@gmail.com.
Satya S KolarCollege of Optometry, University of Houston, Houston, TX 77204, USA. Electronic address: snkolar@uh.edu.
Miguel A Casado-RodriguezDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Málaga, 29071, Spain. Electronic address: miguelcasado204@gmail.com.
Yongkai HuangDepartment of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address: hykaiuh@gmail.com.
Alison McDermottCollege of Optometry, University of Houston, Houston, TX 77204, USA. Electronic address: amcdermott@optometry.uh.edu.
Juan Manuel Lopez-RomeroDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Málaga, 29071, Spain. Electronic address: jmromero@uma.es.
Chengzhi CaiDepartment of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address: cai@uh.edu.
University of Houston · USUniversidad de Málaga · ES

Funding

Role of Antimicrobial Peptides at the Ocular SurfaceR01EY013175 · NEI · UNIVERSITY OF HOUSTON · PI MCDERMOTT, ALISON M · 2001 to 2016
$4.3M
Nanoscale presentation of antimicrobial peptides found at the ocular surfaceR21EY018303 · NEI · UNIVERSITY OF HOUSTON · PI CAI, CHENGZHI · 2009 to 2010
$413k
NEI NIH HHS R01 EY013175NEI NIH HHS R01EY013175-08NEI NIH HHS R21 EY018303NEI NIH HHS R21EY018303
6 · The paper itself

Abstract

In this work perfluorinated substrates fabricated from SiO2 glass slides are modified with oligo(ethylene glycol) (OEG) units for long-term resistance of cell adhesion purposes, based on fluorous interactions and click chemistry. Specifically, fluorous substrates, prepared by treatment of glass slides with 1H, 1H, 2H, 2H-perfluorodecyltrimethoxysilane (FAS17), were coated with ethynyl-OEG-C8F17, followed by covalent attachment of an azido-OEG via copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" reaction. We demonstrate that the resultant surface avoid fibrinogen adsorption and resisted cell adhesion for over 14days. X-ray photoemission spectroscopy (XPS) analysis and contact angle goniometry measurements confirm the presence of the OEG molecules on the fluorous substrates. Bright field optical images show total absence of 3T3 fibroblast cells on the OEG modified fluorinated substrate for 1 and 5days, and a remarkably decrease of cell adhesion at 14days.

Indexed as

Click ChemistryCell AdhesionEthylene GlycolFluorineGlassMolecular StructureSilicon DioxideEthylene GlycolFluorineSilicon DioxideCell adhesion resistanceClick reactionFluorinated substrateFluorine–fluorine interactionOEGProtein resistance

Identifiers

PMID26210101
PMCPMC12011052
OpenAlexW898580043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.