Evidence map›Paper›PMID 26210076›Full record

ArticleVirology2015

Genotype-specific variation in West Nile virus dispersal in California.

Nisha K Duggal, William K Reisen, Ying Fang, Ruchi M Newman, Xiao Yang, Gregory D Ebel, Aaron C Brault

Abstract read
In one paragraph

Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nisha K DuggalDivision of Vector-borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
William K ReisenCenter for Vectorborne Diseases, University of California, Davis, CA, USA.
Ying FangCenter for Vectorborne Diseases, University of California, Davis, CA, USA.
Ruchi M NewmanBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
Xiao YangBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
Gregory D EbelDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.
Aaron C BraultDivision of Vector-borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA. Electronic address: abrault@cdc.gov.

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI EARL, ASHLEE MIRIAM · 2014 to 2024
$66.5M
Quasispecies dynamics in arbovirus persistence emergence and fitnessR01AI067380 · NIAID · UNIVERSITY OF NEW MEXICO · PI Gregory David Ebel · 2007 to 2026
$7.7M
Persistence of West Nile virus in CaliforniaR01AI055607 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI REISEN, WILLIAM K · 2003 to 2012
$4.4M
NIAID NIH HHS AI067380NIAID NIH HHS AI55607NIAID NIH HHS HHSN272200900018CNIAID NIH HHS R01 AI055607NIAID NIH HHS R01 AI067380NIAID NIH HHS U19 AI110818PHS HHS HHSN272200900018
6 · The paper itself

Abstract

West Nile virus (WNV) is an arbovirus that was first reported in North America in New York in 1999 and, by 2003, had spread more than 4000 km to California. However, variation in viral genetics associated with spread is not well understood. Herein, we report sequences for more than 100 WNV isolates made from mosquito pools that were collected from 2003 to 2011 as part of routine surveillance by the California Mosquito-borne Virus Surveillance System. We performed phylogeographic analyses and demonstrated that 5 independent introductions of WNV (1 WN02 genotype strain and 4 SW03 genotype strains) occurred in California. The SW03 genotype of WNV was constrained to the southwestern U.S. and had a more rapid rate of spread. In addition, geographic constraint of WNV strains within a single region for up to 6 years suggest viral maintenance has been driven by resident, rather than migratory, birds and overwintering in mosquitoes.

Indexed as

Genome, ViralAnimalsBayes TheoremBirdsCaliforniaCulexEpidemiological MonitoringGenotypeHigh-Throughput Nucleotide SequencingHumansInsect ProteinsInsect VectorsOpen Reading FramesPhenotypePhylogenyPhylogeographyInsect ProteinsArbovirusEvolutionPhylogeneticsWest Nile virus

Identifiers

PMID26210076
PMCPMC4619151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.