Evidence map›Paper›PMID 26209901›Full record

ReviewImmunology and allergy clinics of North America2015

Novel Therapies for Eosinophilic Disorders.

Bruce S Bochner

Abstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Emerging Evidence for Pleiotropism of Eosinophils.International journal of molecular sciences · 2021
    Review
  7. Review
  8. Article
  9. Review
  10. The eosinophil: For better or worse, in sickness and in health.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018
    Review
  11. Review
  12. Eosinophils in Autoimmune Diseases.Frontiers in immunology · 2017
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Eosinophilic bioactivities in severe asthma.The World Allergy Organization journal · 2016
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Bruce S BochnerDivision of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Street, Room M-306, Chicago, IL 60611, USA. Electronic address: bruce.bochner@northwestern.edu.
Northwestern University · US

Funding

Treating lung inflammation by targeting SiglecsP01HL107151 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SCHNAAR, RONALD L · 2011 to 2017
$15.4M
Anti IL5 and Churg Strauss Syndrome: a double blind, placebo controlled trialU01AI097073 · NIAID · NATIONAL JEWISH HEALTH · PI WECHSLER, MICHAEL E · 2013 to 2016
$5.8M
Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In VivoR01AI072265 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BOCHNER, BRUCE S · 2007 to 2017
$3.9M
Targeting Siglec-8/-F to treat eosinophil and mast cell related disordersR56AI072265 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BOCHNER, BRUCE S · 2012 to 2012
$405k
NHLBI NIH HHS HL107151NHLBI NIH HHS P01 HL107151NIAID NIH HHS AI072265NIAID NIH HHS AI097073NIAID NIH HHS R01 AI072265
6 · The paper itself

Abstract

Current therapies for eosinophilic disorders are limited. Most treatment approaches remain empirical, are not supported by data from controlled clinical trials, involve the off-label use of agents developed for treatment of other diseases, and tend to rely heavily on the use of glucocorticoids and other agents with significant toxicity. Great progress has been made in the discovery, preclinical development, and clinical testing of a variety of biologics and small molecules that have the potential to directly or indirectly influence eosinophils, eosinophilic inflammation, and the consequences of eosinophil activation.

Indexed as

Antibodies, MonoclonalAsthmaCytokinesEosinophilsGlucocorticoidsHumansHypereosinophilic SyndromeMolecular Targeted TherapyReceptors, Cell SurfaceAntibodies, MonoclonalCytokinesGlucocorticoidsReceptors, Cell SurfaceAntibodiesBiomarkersEosinophilPharmacologyTargetsTherapies

Identifiers

PMID26209901
PMCPMC4515571
OpenAlexW2133406974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.