ArticleCerebral cortex (New York, N.Y. : 1991)2016
Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study.Nature medicine · 2023Trial
- Autism spectrum disorder variation as a computational trade-off via dynamic range of neuronal population responses.Nature neuroscience · 2024Article
- Review
- Physiological noise facilitates multiplexed coding of vibrotactile-like signals in somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Article
- Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.PLoS computational biology · 2021Article
- Region-specific elevations of glutamate + glutamine correlate with the sensory symptoms of autism spectrum disorders.Translational psychiatry · 2021Article
- Induction and propagation of transient synchronous activity in neural networks endowed with short-term plasticity.Cognitive neurodynamics · 2021Article
- A Time-Varying Information Measure for Tracking Dynamics of Neural Codes in a Neural Ensemble.Entropy (Basel, Switzerland) · 2020Article
- Mechanisms underlying gain modulation in the cortex.Nature reviews. Neuroscience · 2020Review
- Regulation of gamma-frequency oscillation by feedforward inhibition: A computational modeling study.Hippocampus · 2019Article
- Spontaneous activity in the piriform cortex extends the dynamic range of cortical odor coding.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Control of Absence Seizures by the Thalamic Feed-Forward Inhibition.Frontiers in computational neuroscience · 2017Article
- Snapshots of the Brain in Action: Local Circuit Operations through the Lens of γ Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The cortex encodes a broad range of inputs. This breadth of operation requires sensitivity to weak inputs yet non-saturating responses to strong inputs. If individual pyramidal neurons were to have a narrow dynamic range, as previously claimed, then staggered all-or-none recruitment of those neurons would be necessary for the population to achieve a broad dynamic range. Contrary to this explanation, we show here through dynamic clamp experiments in vitro and computer simulations that pyramidal neurons have a broad dynamic range under the noisy conditions that exist in the intact brain due to background synaptic input. Feedforward inhibition capitalizes on those noise effects to control neuronal gain and thereby regulates the population dynamic range. Importantly, noise allows neurons to be recruited gradually and occludes the staggered recruitment previously attributed to heterogeneous excitation. Feedforward inhibition protects spike timing against the disruptive effects of noise, meaning noise can enable the gain control required for rate coding without compromising the precise spike timing required for temporal coding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.