Evidence map›Paper›PMID 26209821›Full record

ReviewCurrent opinion in structural biology2015

Assessing and maximizing data quality in macromolecular crystallography.

P Andrew Karplus, Kay Diederichs

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed.

  1. Article
  2. Engineering a protein homodimer from a heterodimer: A chimeric DBHS protein.Protein science : a publication of the Protein Society · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Crystal structure of human Dickkopf 4 cysteine-rich domain 1 and evaluation of conformational rigidity.Acta crystallographica. Section F, Structural biology communications · 2026
    Article
  7. Unusual backfolded binding poses of BAZ2A bromodomain binders.Acta crystallographica. Section D, Structural biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Automated gradient equilibration of macromolecular crystals to new solution conditions.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  15. Article
  16. Structures of Listeria monocytogenes MenD in ThDP-bound and in-crystallo captured intermediate I-bound forms.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  17. Article
  18. Standards for MicroED.Acta crystallographica. Section C, Structural chemistry · 2025
    Article
  19. Article
  20. Structures of Mycobacterium tuberculosis isoprenyl diphosphate synthase Rv2173 in substrate-bound forms.Acta crystallographica. Section F, Structural biology communications · 2025
    Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

P Andrew KarplusDepartment of Biochemistry & Biophysics, Oregon State University, Corvallis, OR 97331, USA. Electronic address: karplusp@science.oregonstate.edu.
Kay DiederichsUniversity of Konstanz, Faculty of Biology, Box 647, D-78457 Konstanz, Germany. Electronic address: kay.diederichs@uni-konstanz.de.

Funding

Improving Modeling by Learning from Details of High Accuracy Protein StructuresR01GM083136 · NIGMS · OREGON STATE UNIVERSITY · PI KARPLUS, PAUL ANDREW · 2008 to 2015
$1.7M
NIGMS NIH HHS GM083136NIGMS NIH HHS R01 GM083136
6 · The paper itself

Abstract

The quality of macromolecular crystal structures depends, in part, on the quality and quantity of the data used to produce them. Here, we review recent shifts in our understanding of how to use data quality indicators to select a high resolution cutoff that leads to the best model, and of the potential to greatly increase data quality through the merging of multiple measurements from multiple passes of single crystals or from multiple crystals. Key factors supporting this shift are the introduction of more robust correlation coefficient based indicators of the precision of merged data sets as well as the recognition of the substantial useful information present in extensive amounts of data once considered too weak to be of value.

Indexed as

Data AccuracyModels, MolecularCrystallography, X-RayMacromolecular SubstancesSignal-To-Noise RatioMacromolecular Substances

Identifiers

PMID26209821
PMCPMC4684713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.