Evidence map›Paper›PMID 26209557›Full record

ArticleToxicological sciences : an official journal of the Society of Toxicology2015

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study.

Matthew O Gribble, Venkata Saroja Voruganti, Shelley A Cole, Karin Haack, Poojitha Balakrishnan, Sandra L Laston, Maria Tellez-Plaza, Kevin A Francesconi, Walter Goessler, Jason G Umans and 5 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicological sciences : an official journal of the Society of Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Matthew O Gribble*Department of Preventive Medicine, University of Southern California, Los Angeles, California; mgribble@usc.edu.
Venkata Saroja VorugantiDepartment of Nutrition, University of North Carolina, Chapel Hill, North Carolina; UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina;
Shelley A ColeDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas;
Karin HaackDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas;
Poojitha BalakrishnanDepartment of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland; Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, Maryland;
Sandra L LastonSouth Texas Diabetes and Obesity Institute, University of Texas Health Science Center, San Antonio-Regional Academic Health Center, Brownsville, Texas;
Maria Tellez-PlazaDepartment of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland; Biomedical Research Institute, Hospital Clinic de Valencia-INCLIVA, Valencia, Spain;
Kevin A FrancesconiInstitute of Chemistry-Analytical Chemistry, University of Graz, Graz, Austria;
Walter GoesslerInstitute of Chemistry-Analytical Chemistry, University of Graz, Graz, Austria;
Jason G UmansGeorgetown-Howard Universities Center for Clinical and Translational Science, Washington, District of Columbia; MedStar Health Research Institute, Hyattsville, Maryland;
Duncan C Thomas*Department of Preventive Medicine, University of Southern California, Los Angeles, California;
Frank Gilliland*Department of Preventive Medicine, University of Southern California, Los Angeles, California;
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina;
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina;
Ana Navas-AcienDepartment of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland; Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, Maryland; Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Johns Hopkins University · USUniversity of Southern California · USGraz University of Technology · ATTexas Biomedical Research Institute · USUniversity of North Carolina at Chapel Hill · USDavid H. Murdock Research Institute · USMedStar Health · USThe University of Texas Health Science Center at San Antonio · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
CARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
CVD in American Indians Study and Data Management Center and OK Field CenterR01HL109284 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STONER, JULIE A · 2013 to 2018
$4.6M
CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3M
CVD in American Indians Genetics CenterR01HL109301 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2013 to 2018
$3.2M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR017515 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 2003 to 2003
$3.1M
Arsenic Exposure, Cardiovascular Disease and Diabetes in Native AmericansR01HL090863 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NAVAS-ACIEN, ANA · 2008 to 2011
$3.1M
NCRR NIH HHS C06 RR013556NCRR NIH HHS C06 RR017515NHLBI NIH HHS HL41642NHLBI NIH HHS HL41652NHLBI NIH HHS HL41654NHLBI NIH HHS HL65521NHLBI NIH HHS R01 HL090863NHLBI NIH HHS R01HL090863NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065521NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES021367NIEHS NIH HHS R01ES021367NIEHS NIH HHS T32 ES013678NIEHS NIH HHS T32ES013678-07
6 · The paper itself

Abstract

Arsenic toxicokinetics are important for disease risks in exposed populations, but genetic determinants are not fully understood. We examined urine arsenic species patterns measured by HPLC-ICPMS among 2189 Strong Heart Study participants 18 years of age and older with data on ~400 genome-wide microsatellite markers spaced ~10 cM and arsenic speciation (683 participants from Arizona, 684 from Oklahoma, and 822 from North and South Dakota). We logit-transformed % arsenic species (% inorganic arsenic, %MMA, and %DMA) and also conducted principal component analyses of the logit % arsenic species. We used inverse-normalized residuals from multivariable-adjusted polygenic heritability analysis for multipoint variance components linkage analysis. We also examined the contribution of polymorphisms in the arsenic metabolism gene AS3MT via conditional linkage analysis. We localized a quantitative trait locus (QTL) on chromosome 10 (LOD 4.12 for %MMA, 4.65 for %DMA, and 4.84 for the first principal component of logit % arsenic species). This peak was partially but not fully explained by measured AS3MT variants. We also localized a QTL for the second principal component of logit % arsenic species on chromosome 5 (LOD 4.21) that was not evident from considering % arsenic species individually. Some other loci were suggestive or significant for 1 geographical area but not overall across all areas, indicating possible locus heterogeneity. This genome-wide linkage scan suggests genetic determinants of arsenic toxicokinetics to be identified by future fine-mapping, and illustrates the utility of principal component analysis as a novel approach that considers % arsenic species jointly.

Indexed as

Genetic Predisposition to DiseaseMicrosatellite RepeatsAdultArizonaArsenicalsArsenic PoisoningBiomarkersBiotransformationCohort StudiesFemaleGenetic LinkageGenome-Wide Association StudyHumansLinkage DisequilibriumLogistic ModelsMaleArsenicalsAS3MT protein, humanBiomarkersMethyltransferasesarsenic metabolismarsenic specieslinkage analysisStrong Heart Family Studytoxicogeneticstoxicokinetics

Identifiers

PMID26209557
PMCPMC4731407
OpenAlexW2135016992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.