ArticleThe Annals of thoracic surgery2015
Red Blood Cell Transfusions Impact Pneumonia Rates After Coronary Artery Bypass Grafting.
Article in The Annals of thoracic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02073760 (Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery), which is not on this map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Development and validation of a risk prediction model for postoperative pneumonia in adult patients undergoing Stanford type A acute aortic dissection surgery: a case control study.Journal of cardiothoracic surgery · 2022Trial
- Autologous cell salvage in off-pump coronary artery bypass surgery reduces post-operative complications: a retrospective weighted-matching analysis.General thoracic and cardiovascular surgery · 2024Article
- Study on risk factors and treatment strategies of hypoxemia after acute type a aortic dissection surgery.Journal of cardiothoracic surgery · 2024Review
- Clinical Predictors and Outcomes After Left Ventricular Assist Device Implantation and Tracheostomy.Texas Heart Institute journal · 2023Article
- Nomogram and Risk Calculator for Postoperative Tracheostomy after Heart Valve Surgery.Journal of cardiovascular development and disease · 2023Article
- Appropriateness of Allogeneic Red Blood Cell Transfusions in Non-Bleeding Patients in a Large Teaching Hospital: A Retrospective Study.Journal of clinical medicine · 2023Article
- Pneumonia After Cardiovascular Surgery: Incidence, Risk Factors and Interventions.Frontiers in cardiovascular medicine · 2022Review
- Establishment and Validation of a Nomogram to Predict Hospital-Acquired Infection in Elderly Patients After Cardiac Surgery.Clinical interventions in aging · 2022Article
- Effects of implementing rotational thromboelastometry in cardiac surgery: A retrospective cohort study.Journal of perioperative practice · 2021Article
- Risk factors for postoperative pneumonia after cardiac surgery: a prediction model.Journal of thoracic disease · 2021Article
- Article
- Development and Validation of Nomogram Models for Postoperative Pneumonia in Adult Patients Undergoing Elective Cardiac Surgery.Frontiers in cardiovascular medicine · 2021Article
- Did blood transfusion increase mortality in patients with diabetes undergoing isolated coronary artery bypass graft surgery? A propensity score-matched analysis of 816 patients.Turk gogus kalp damar cerrahisi dergisi · 2020Article
- Article
- Article
- The bloody mess of red blood cell transfusion.Critical care (London, England) · 2017Review
- Organizational Contributors to the Variation in Red Blood Cell Transfusion Practices in Cardiac Surgery: Survey Results From the State of Michigan.Anesthesia and analgesia · 2017Article
- Longitudinal Study of Transfusion Utilization in Hospitalized Veterans.Journal of clinical outcomes management : JCOM · 2017Article
- The Epidemiology and Risk Factors for Postoperative Pneumonia.Journal of clinical medicine research · 2017Review
- Mild volume acute normovolemic hemodilution is associated with lower intraoperative transfusion and postoperative pulmonary infection in patients undergoing cardiac surgery -- a retrospective, propensity matching study.BMC anesthesiology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPneumonia, a known complication of coronary artery bypass grafting (CABG), significantly increases a patient's risk of morbidity and mortality. Although not well characterized, red blood cell (RBC) transfusions may increase a patient's risk of pneumonia. We describe the relationship between RBC transfusion and postoperative pneumonia after CABG.
methodsA total of 16,182 consecutive patients underwent isolated CABG between 2011 and 2013 at 1 of 33 hospitals in the state of Michigan. We used multivariable logistic regression to estimate the relative odds of pneumonia associated with the use or number of RBC units (0, 1, 2, 3, 4, 5, and ≥ 6). We adjusted for predicted risk of mortality, preoperative hematocrit values, history of pneumonia, cardiopulmonary bypass duration, and medical center. We confirmed the strength and direction of these relationships among selected clinical subgroups in a secondary analysis.
resultsFive hundred seventy-six (3.6%) patients had pneumonia and 6,451 (39.9%) received RBC transfusions. There was a significant association between any RBC transfusion and pneumonia (adjusted odds ratio [ORadj], 3.4; p < 0.001). There was a dose response between number of units and odds of pneumonia, with a ptrend less than 0.001. Patients receiving only 2 units of RBCs had a 2-fold (ORadj, 2.1; p < 0.001) increased odds of developing pneumonia. These findings were consistent across clinical subgroups.
conclusionsWe found a significant volume-dependent association between an increasing number of RBCs and the odds of pneumonia, which persisted after risk adjustment. Clinical teams should explore opportunities for preventing a patient's risk of RBC transfusions, including reducing hemodilution or adopting a lower transfusion threshold in a stable patient.
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