Evidence map›Paper›PMID 26209464›Full record

ReviewTrends in neurosciences2015

The cellular and molecular landscape of neuroligins.

Michael A Bemben, Seth L Shipman, Roger A Nicoll, Katherine W Roche

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 174 citations in OpenAlex.

  1. Review
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  6. Review
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  8. Localization and Functional Characterization of MDGA1 in Mouse Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  9. Article
  10. Genetic interaction ofFrontiers in neuroscience · 2026
    Article
  11. Review
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  14. Article
  15. Article
  16. Article
  17. Review
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Michael A BembenReceptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA; Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA.
Seth L ShipmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Roger A NicollDepartments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: roger.nicoll@ucsf.edu.
Katherine W RocheReceptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: rochek@mail.nih.gov.
National Institute of Neurological Disorders and Stroke · USHarvard University · USUniversity of California, San Francisco · US

Funding

Regulation of Neuroligins and Effects on Synapse Number and FunctionZIANS003140 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROCHE, KATHERINE · 2014 to 2025
$20.5M
Synaptic Plasticity Regulated by Stargazin-like gamma-8R01MH070957 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NICOLL, ROGER A · 2004 to 2019
$6.3M
NIMH NIH HHS R01 MH070957
6 · The paper itself

Abstract

A fundamental physical interaction exists across the synapse. It is mediated by synaptic adhesion molecules, and is among the earliest and most indispensable of molecular events occurring during synaptogenesis. The regulation of adhesion molecules and their interactions with other synaptic proteins likely affect not only on synapse formation but also on ongoing synaptic function. We review research on one major family of postsynaptic adhesion molecules, neuroligins, which bind to their presynaptic partner neurexin across the synaptic cleft. We move from a structural overview to the broad cellular and synaptic context of neuroligins, intermolecular interactions, and molecular modifications that occur within a synapse. Finally, we examine evidence concerning the physiological functions of neuroligin in a cell and highlight areas requiring further investigation.

Indexed as

Amino Acid SequenceAnimalsCell Adhesion Molecules, NeuronalHumansLigandsModels, NeurologicalMolecular Sequence DataNeuronal PlasticityProtein Interaction Domains and MotifsProtein MultimerizationSynapsesCell Adhesion Molecules, NeuronalLigands

Identifiers

PMID26209464
PMCPMC9381026
OpenAlexW1553785885

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.