ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2015
Genomic characterization of a persistent rubella virus from a case of Fuch' uveitis syndrome in a 73 year old man.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical and immunological spectrum of MHC class I deficiency: insights from a long-term cohort with two novel mutations.Frontiers in immunology · 2025Article
- Molecular epidemiology of rubella during the pre- and post-elimination eras in the Americas.Revista panamericana de salud publica = Pan American journal of public health · 2024Article
- Rubella Virus Infected Macrophages and Neutrophils Define Patterns of Granulomatous Inflammation in Inborn and Acquired Errors of Immunity.Frontiers in immunology · 2021Article
- Deep Sequencing of Varicella-Zoster Virus in Aqueous Humor From a Patient With Acute Retinal Necrosis Presenting With Acute Glaucoma.Open forum infectious diseases · 2020Article
- Association of Ocular Inflammation and Rubella Virus Persistence.JAMA ophthalmology · 2019Article
- Outcomes for Nitazoxanide Treatment in a Case Series of Patients with Primary Immunodeficiencies and Rubella Virus-Associated Granuloma.Journal of clinical immunology · 2019Article
- Inhibition of rubella virus replication by the broad-spectrum drug nitazoxanide in cell culture and in a patient with a primary immune deficiency.Antiviral research · 2017Article
- Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens.Genome medicine · 2016Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundMany cases of Fuchs' uveitis have been associated with persistent rubella virus infection. A 73-year-old male patient with typical Fuchs' Uveitis Syndrome (FUS) first experienced heterochromia of the left eye at the age fourteen, when rubella was endemic in the US.
objectivesThe purposes of this report are to describe the patient's FUS clinical presentations and to characterize the virus detected in the vitreous fluid. STUDY
designThe patient underwent a therapeutic pars plana vitrectomy in May 2013. A real-time RT-PCR assay for rubella virus was performed on the vitreous fluid by Focus Diagnostics. Additional real-time RT-PCR assays for rubella virus detection and RT-PCR assays for generation of templates for sequencing were performed at the Centers for Disease Control and Prevention (CDC).
resultsThe results from Focus Diagnostics were positive for rubella virus RNA. Real-time RT-PCR assays at CDC were also positive for rubella virus. A rubella virus sequence of 739 nucleotides was determined and phylogenetic analysis showed that the virus was the sole member of a new phylogenetic group when compared to reference virus sequences.
conclusionsWhile FUS remains a clinical diagnosis, findings in this case support the association between rubella virus and the disease. Phylogenetic analysis provided evidence that this rubella virus was likely a previously undetected genotype which is no longer circulating. Since the patient had rubella prior to 1955, this sequence is from the earliest rubella virus yet characterized.
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