Trial reportClinical and experimental nephrology2016
The effectiveness and safety of modest exercise in Japanese patients with chronic kidney disease: a single-armed interventional study.
Trial report in Clinical and experimental nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Whole body resistance training on functional outcomes of patients with Stage 4 or 5 chronic kidney disease: A systematic review.Physiological reports · 2024Pooled it
- Effects of exercise training on proteinuria in adult patients with chronic kidney disease: a systematic review and meta-analysis.BMC nephrology · 2020Pooled it
- Survival in patients with CKD 3-5 after 12 months of exercise training - a post-hoc analysis of the RENEXC trial.BMC nephrology · 2025Trial
- Rhythmic Walking Exercise as a Low-Intensity Strategy to Enhance Health and Preserve Kidney Function in Individuals with CKD Stages 2-3.Life (Basel, Switzerland) · 2025Article
- Combined sedentarism and high-fat diet induce early signs of kidney injury in C57BL/6J mice.American journal of physiology. Renal physiology · 2025Article
- Six months of physical inactivity is insufficient to cause chronic kidney disease in C57BL/6J mice.bioRxiv : the preprint server for biology · 2024Article
- Effects of Different Types of Exercise on Kidney Diseases.Sports (Basel, Switzerland) · 2022Review
- Physical Exercise in People with Chronic Kidney Disease-Practices and Perception of the Knowledge of Health Professionals and Physical Activity and Sport Science Professionals about Their Prescription.International journal of environmental research and public health · 2022Article
- Association of Daily Physical Activity with Disability in Community-Dwelling Older Adults With/Without Chronic Kidney Disease.The journal of nutrition, health & aging · 2022Observational
- Effect of an exercise rehabilitation program on physical function over 1 year in chronic kidney disease: an observational study.Clinical kidney journal · 2020Article
- Exercise as a prescription for patients with various diseases.Journal of sport and health science · 2019Review
- The Effect of Chronic Kidney Disease on a Physical Activity Intervention: Impact on Physical Function, Adherence, and Safety.Journal of clinical nephrology and renal care · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor physical ability and skeletal muscle wasting are common in chronic kidney disease (CKD) patients, who may experience a decline in daily activity and, in turn, increased mortality. The purpose of this study was to evaluate the effectiveness and safety of modest exercise in patients with stable CKD.
methodsForty-seven CKD patients were enrolled in a 6-month group program for aerobic and resistance exercise by self-training. Parameters of physical function and clinical laboratory markers, including renal function, were measured.
resultsThe International Physical Activity Questionnaire score improved from a baseline of 36.6 ± 13.8 to 40.1 ± 14.8 after the exercise program (P < 0.001). The number of daily steps increased from 6141 ± 2620 to 7679 ± 3026 (P < 0.001). We detected significant changes in the 30-s chair stand test (from 20.7 ± 5.3 to 26.0 ± 5.9 repetitions; P < 0.001), single-foot standing test (from 53.0 ± 44.3 to 68.4 ± 43.0 s; P = 0.001) and 6-min walk (from 501.6 ± 63.8 to 528.7 ± 71.8 m; P = 0.02). Moreover, body weight, waist circumference, and blood pressure were significantly reduced. No significant deterioration was observed in the estimated glomerular filtration rate. Proteinuria significantly decreased in 21 patients.
conclusionOur modest exercise program improved the physical performance of CKD patients without deterioration of renal function. These results suggest that exercise rather than excess rest should be recommended for CKD patients to avoid muscle wasting.
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Registered trials
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