ArticleNeuroImage2015
MRI compatible optrodes for simultaneous LFP and optogenetic fMRI investigation of seizure-like afterdischarges.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- WISDEM: a hybrid wireless integrated sensing detector for simultaneous EEG and MRI.Nature methods · 2025Article
- Article
- Seizure network characterization by functional connectivity mapping and manipulation.Neurophotonics · 2025Article
- Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI.Frontiers in neuroimaging · 2024Article
- Brain-wide ongoing activity is responsible for significant cross-trial BOLD variability.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI.Science (New York, N.Y.) · 2022Review
- Distinct local and brain-wide networks are activated by optogenetic stimulation of neurons specific to each layer of motor cortex.NeuroImage · 2022Article
- Toward Completely Sampled Extracellular Neural Recording During fMRI.IEEE transactions on medical imaging · 2022Article
- Hybrid fiber optic-fMRI for multimodal cell-specific recording and manipulation of neural activity in rodents.Neurophotonics · 2022Review
- Repeated hippocampal seizures lead to brain-wide reorganization of circuits and seizure propagation pathways.Neuron · 2022Article
- Combining magnetic resonance imaging with readout and/or perturbation of neural activity in animal models: Advantages and pitfalls.Frontiers in neuroscience · 2022Review
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- Hybrid Electrical and Optical Neural Interfaces.Journal of micromechanics and microengineering : structures, devices, and systems · 2021Article
- Predicting Successful Generation and Inhibition of Seizure-like Afterdischarges and Mapping Their Seizure Networks Using fMRI.Cell reports · 2020Article
- Article
- Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus.Nature communications · 2019Article
- Carbon monofilament electrodes for unit recording and functional MRI in same subjects.NeuroImage · 2019Article
- Novel Optogenetic Approaches in Epilepsy Research.Frontiers in neuroscience · 2019Review
- The Role of EEG-fMRI in Studying Cognitive Network Alterations in Epilepsy.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In preclinical studies, implanted electrodes can cause severe degradation of MRI images and hence are seldom used for chronic studies employing functional magnetic resonance imaging. In this study, we developed carbon fiber optrodes (optical fiber and electrode hybrid devices), which can be utilised in chronic longitudinal studies aiming to take advantage of emerging optogenetic technologies, and compared them with the more widely used tungsten optrodes. We find that optrodes constructed using small diameter (~130 μm) carbon fiber electrodes cause significantly reduced artifact on functional MRI images compared to those made with 50 μm diameter tungsten wire and at the same time the carbon electrodes have lower impedance, which leads to higher quality LFP recordings. In order to validate this approach, we use these devices to study optogenetically-induced seizure-like afterdischarges in rats sedated with dexmedetomidine and compare these to sub (seizure) threshold stimulations in the same animals. The results indicate that seizure-like afterdischarges involve several extrahippocampal brain regions that are not recruited by subthreshold optogenetic stimulation of the hippocampus at 20 Hz. Subthreshold stimulation led to activation of the entire ipsilateral hippocampus and septum, whereas afterdischarges additionally produced activations in the contralateral hippocampal formation, neocortex, cerebellum, nucleus accumbens, and thalamus. Although we demonstrate just one application, given the ease of fabrication, we anticipate that carbon fiber optrodes could be utilised in a variety of studies that could benefit from longitudinal optogenetic functional magnetic resonance imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.