SynthesisBMC medical genetics2015
Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis.
Synthesis in BMC medical genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Folic acid/methylfolate for the treatment of psychopathology in schizophrenia: a systematic review and meta-analysis.Psychopharmacology · 2018Pooled it
- Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- Higher peripheral blood homocysteine levels are associated with schizophrenia: evidence from a case-control study and a meta-analysis.Molecular psychiatry · 2026Article
- The interplay between homocysteine, oxidative stress, and butyrylcholinesterase activity in the pathogenesis of schizophrenia.BMC psychiatry · 2025Article
- Article
- Association of homocysteine with white matter dysconnectivity in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women.International journal of molecular sciences · 2023Article
- Homocysteine-Potential Novel Diagnostic Indicator of Health and Disease in Horses.Animals : an open access journal from MDPI · 2023Review
- Genetic association between circulating selenium level and the risk of schizophrenia in the European population: A two-sample Mendelian randomization study.Frontiers in nutrition · 2022Article
- Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups.Scientific reports · 2021Article
- Involvements of Hyperhomocysteinemia in Neurological Disorders.Metabolites · 2021Review
- Homocysteine in Schizophrenia: Independent Pathogenetic Factor with Prooxidant Activity or Integral Marker of Other Biochemical Disturbances?Schizophrenia research and treatment · 2021Article
- Gene interactions observed with the HDL-c blood lipid, intakes of protein, sugar and biotin in relation to circulating homocysteine concentrations in a group of black South Africans.Molecular genetics and metabolism reports · 2020Article
- Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach.European journal of nutrition · 2020Article
- Mendelian randomisation for nutritional psychiatry.The lancet. Psychiatry · 2020Review
- Comparison of serum levels of asymmetric dimethylarginine between patients who take two types of atypical anti psychotics.Medical journal of the Islamic Republic of Iran · 2019Article
- Article
- A Mendelian Randomization Study of Plasma Homocysteine and Multiple Myeloma.Scientific reports · 2016Article
- Improvement of Psychotic Symptoms and the Role of Tissue Plasminogen Activator.International journal of molecular sciences · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe results of meta-analyses conducted by previous association studies between total homocysteine and schizophrenia suggest that an elevated total homocysteine level is a risk factor for schizophrenia. However, observational studies have potential limitations, such as confounding and reverse causation. In the present study, we evaluated a causal relationship between plasma total homocysteine and schizophrenia by conducting a Mendelian randomization analysis.
methodsWe used the MTHFR C677T polymorphism as an instrumental variable, which affects the plasma total homocysteine levels. To calculate the risk estimate for the association of this single nucleotide polymorphism (SNP) with schizophrenia, we conducted a meta-analysis of case-control studies that comprise a total of 11,042 patients with schizophrenia and 14,557 control subjects. We obtained an estimate for the association of this SNP with the plasma total homocysteine levels from a meta-analysis of genome-wide association studies comprising 44,147 individuals.
resultsBy combining these two estimates, we demonstrated a significant effect of the plasma total homocysteine on schizophrenia risk, representing an OR of 2.15 (95 % CI = 1.39-3.32; p = 5.3 x 10(-4)) for schizophrenia per 1-SD increase in the natural log-transformed plasma total homocysteine levels.
conclusionsWe provided evidence of a causal relationship between the plasma total homocysteine and schizophrenia, and this result will add insight into the pathology and treatment of schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.