ArticlePsychiatry research2015
Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study.
Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Activation of the motivation-related ventral striatum during delusional experience.Translational psychiatry · 2018Pooled it
- Twin differences in the Minnesota Trust Game relate to neural mechanisms of suspiciousness.Cognitive, affective & behavioral neuroscience · 2025Article
- Distress and Negative Subtypes of Schizophrenia: Identification, Characterization, and Neurostructural Profiles.Schizophrenia bulletin open · 2025Article
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework.Biological psychiatry global open science · 2024Review
- Threat Responses in Schizophrenia: A Negative Valence Systems Framework.Current psychiatry reports · 2024Review
- Convergent and divergent gray matter volume abnormalities in unaffected first-degree relatives and ultra-high risk individuals of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Task-related neural mechanisms of persecutory ideation in schizophrenia and community monozygotic twin-pairs.Human brain mapping · 2021Article
- MicroRNAs in the Onset of Schizophrenia.Cells · 2021Review
- BNST and amygdala connectivity are altered during threat anticipation in schizophrenia.Behavioural brain research · 2021Article
- Aberrant anterior cingulate processing of anticipated threat as a mechanism for psychosis.Psychiatry research. Neuroimaging · 2021Article
- Abnormal semantic processing of threat words associated with excitement and hostility symptoms in schizophrenia.Schizophrenia research · 2021Article
- Risk-taking and fairness among cocaine-dependent patients in dual diagnoses: Schizophrenia and Anti-Social Personality Disorder.Scientific reports · 2020Article
- Abnormal cerebellar volume in somatic vs. non-somatic delusional disorders.Cerebellum & ataxias · 2020Article
- Episodic memory for visual scenes suggests compensatory brain activity in breast cancer patients: a prospective longitudinal fMRI study.Brain imaging and behavior · 2019Article
- Functional connectivity during affective mentalizing in criminal offenders with psychotic disorders: Associations with clinical symptoms.Psychiatry research. Neuroimaging · 2018Article
- Self-regulating positive emotion networks by feedback of multiple emotional brain states using real-time fMRI.Experimental brain research · 2016Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
Abstract
Persecutory delusions are a clinically important symptom in schizophrenia associated with social avoidance and increased violence. Few studies have investigated the neurobiology of persecutory delusions, which is a prerequisite for developing novel treatments. The aim of this two-paradigm functional magnetic resonance imaging (fMRI) study is to characterize social "real world" and linguistic threat brain activations linked to persecutory delusions in schizophrenia (n=26) using instructed-fear/safety and emotional word paradigms. Instructed-fear/safety activations correlated to persecutory delusion severity demonstrated significant increased lateral orbitofrontal cortex and visual association cortex activations for the instructed-fear vs. safety and instructed-fear vs. baseline contrasts; decreased lateral orbitofrontal cortex and ventral occipital-temporal cortex activations were observed for the instructed-safety stimuli vs. baseline contrast. The salience network also showed divergent fear and safety cued activations correlated to persecutory delusions. Emotional word paradigm analyses showed positive correlations between persecutory delusion severity and left-lateralized linguistic and hippocampal-parahippocampal activations for the threat vs. neutral word contrast. Visual word form area activations correlated positively with persecutory delusions for both threat and neutral word vs. baseline contrasts. This study links persecutory delusions to enhanced neural processing of threatening stimuli and decreased processing of safety cues, and helps elucidate systems-level activations associated with persecutory delusions in schizophrenia.
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