Evidence map›Paper›PMID 26208723›Full record

ReviewBiochimica et biophysica acta2015

LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer.

Arunoday Bhan, Subhrangsu S Mandal

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 305 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 2 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

305 citing papers in PubMed, 2 syntheses or guidelines pooled it, 463 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Methylation marks breast cancer metastasis: The roles of mThe Journal of biological chemistry · 2026
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  13. Long Noncoding RNAs as Blood-Based Biomarkers of Diabetic Retinopathy.Translational vision science & technology · 2026
    Article
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245 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Arunoday BhanDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States.
Subhrangsu S MandalDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States. Electronic address: smandal@uta.edu.
The University of Texas at Arlington · US

Funding

Endocrine Disruptors: Assessment of endocrine disruption activity, mechanism andR15ES019129 · NIEHS · UNIVERSITY OF TEXAS ARLINGTON · PI MANDAL, SUBHRANGSU S · 2010 to 2010
$445k
NIEHS NIH HHS 1R15 ES019129NIEHS NIH HHS R15 ES019129
6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in various cellular and physiological processes such as in gene regulation, chromatin dynamics, cell differentiation, and development. NcRNAs are dysregulated in a variety of human disorders including cancers, neurological disorders, and immunological disorders. The mechanisms through which ncRNAs regulate various biological processes and human diseases still remain elusive. HOX antisense intergenic RNA (HOTAIR) is a recently discovered long non-coding RNA (lncRNA) that plays critical role in gene regulation and chromatin dynamics, appears to be misregulated in a variety of cancers. HOTAIR interacts with key epigenetic regulators such as histone methyltransferase PRC2 and histone demethylase LSD1 and regulates gene silencing. Here, we have reviewed recent advancements in understanding the functions and regulation of HOTAIR and its association with cancer and other diseases.

Indexed as

ChromatinHumansNeoplasmsRNA, Long NoncodingChromatinHOTAIR long untranslated RNA, humanRNA, Long NoncodingCancerEpigeneticsHOTAIRLncRNANon-coding RNA

Identifiers

PMID26208723
PMCPMC4544839
OpenAlexW964275744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.