ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2015
Role of nitric oxide in immune responses against viruses: beyond microbicidal activity.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Immune Tolerance vs. Immune Resistance: The Interaction Between Host and Pathogens in Infectious Diseases.Frontiers in veterinary science · 2022Pooled it
- Article
- Peptide-Based Approaches for Pain Relief and Healing in Wounds.International journal of molecular sciences · 2026Review
- Unraveling the Biology of Interferon-Stimulated Genes: Mechanisms, Functions, and Clinical Implications.Infection and drug resistance · 2026Review
- Evaluation of Polymyxin B as a Novel Vaccine Adjuvant and Its Immunological Comparison with FDA-Approved Adjuvants.Vaccines · 2025Article
- Targeting Arginine Metabolism in Immune Cells for the Treatment of Pulmonary Inflammatory Diseases.Current allergy and asthma reports · 2025Review
- Unraveling Macrophage Polarization: Functions, Mechanisms, and "Double-Edged Sword" Roles in Host Antiviral Immune Responses.International journal of molecular sciences · 2024Review
- The Intestinal Barrier Protective Effect of Indole Aldehyde Derivatives on AcuteMolecules (Basel, Switzerland) · 2024Article
- Nitric Oxide Signaling and Sensing in Age-Related Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Studies of the Impact of the Bifidobacterium Species on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Murine Macrophages of the BMDM Cell Line.Probiotics and antimicrobial proteins · 2024Article
- Article
- Innate Immune-Enhancing Effect ofJournal of microbiology and biotechnology · 2024Article
- Potential Mechanisms for Organoprotective Effects of Exogenous Nitric Oxide in an Experimental Study.Biomedicines · 2024Article
- Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients.Diseases (Basel, Switzerland) · 2024Review
- Gene expression levels associated with impaired immune response and increased proliferation could serve as biomarkers for women following cervical cancer screening programmes.Frontiers in immunology · 2024Article
- Hepatic macrophages play critical roles in the establishment and growth of hydatid cysts in the liver during Echinococcus granulosus sensu stricto infection.PLoS neglected tropical diseases · 2023Article
- An Adjuvanted Inactivated SARS-CoV-2 Microparticulate Vaccine Delivered Using Microneedles Induces a Robust Immune Response in Vaccinated Mice.Pharmaceutics · 2023Article
- Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases.Inflammopharmacology · 2023Review
- Impact of Protein Nitration on Influenza Virus Infectivity and Immunogenicity.Microbiology spectrum · 2022Article
- Bio-inspired hemocompatible surface modifications for biomedical applications.Progress in materials science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNitric oxide (NO) is a free radical produced during L-arginine metabolism. In addition to its physiological activities in vascular and neuronal functions, its role in the immune system as a microbicide and tumor-killing mediator has been well described, as well as its release by activated macrophages. Furthermore, NO is produced by a variety of immune and non-immune cells and is involved in the regulation of several immune functions, such as T-cell polarization and suppression.
resultsViral infections generally promote NO production; however, according to its concentration, NO can trigger different effector mechanisms in immune responses. NO can activate the second messenger cyclic guanosine monophosphate (cGMP), can increase the cytoplasmic p53 tumor suppressor molecule, and can modify host and viral molecules by nitrosylation. Because of its microbicide function, NO has frequently been considered a protective mediator in viral infections; however, in some cases NO could be deleterious, potentiating inflammation or contributing to virus latency.
conclusionsThus, advances in the knowledge of the role of NO in immunomodulation and in the pathogenesis of viral diseases could contribute not only to the development of vaccines and therapeutic strategies but also to the use of its metabolites (nitrate/nitrite) and the enzyme responsible for its production (iNOS) as prognostic markers of some of these viral infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.