Evidence map›Paper›PMID 26208604›Full record

ArticleInflammation2015

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.

Brett D Noerager, Xin Xu, Virginia A Davis, Caleb W Jones, Svetlana Okafor, Alicia Whitehead, J Edwin Blalock, Patricia L Jackson

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Acrolein Promotes Retinal Inflammation Through Macrophage Chemotaxis by Inducing CCL2 Production From Müller Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Brett D NoeragerDepartment of Biology, Chemistry, and Mathematics, University of Montevallo, Montevallo, AL, 35115, USA. noeragerb@montevallo.edu.
Xin XuDepartment of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Virginia A DavisDepartment of Biology, Chemistry, and Mathematics, University of Montevallo, Montevallo, AL, 35115, USA.
Caleb W JonesDepartment of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Svetlana OkaforDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Alicia WhiteheadDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
J Edwin BlalockDepartment of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Patricia L JacksonDepartment of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
University of Alabama at Birmingham · USUniversity of Montevallo · USBirmingham VA Medical Center · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
HL-A New Pathway for Neutrophil-induced Airway InflammationR01HL077783 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2006 to 2016
$3.2M
Acquired LTA4H Dysfunction in COPDR01HL110950 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$2.0M
Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation inR01HL090999 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2007 to 2010
$1.5M
Therapeutics for Chronic Lung Diseases: Antagonists of PGP, Chemokines and CXCRR01HL087824 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2009 to 2010
$823k
MODELING OF CARDIAC ARRHYTHMIA GENERATORSF33HL007783 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI GESELOWITZ, DAVID B. · 1988 to 1988
–
NHLBI NIH HHS HL07783NHLBI NIH HHS HL087824NHLBI NIH HHS HL090999NHLBI NIH HHS R01 HL077783NHLBI NIH HHS R01 HL087824NHLBI NIH HHS R01 HL090999NHLBI NIH HHS R01 HL110950NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

Neutrophils (PMNs) are key mediators of inflammatory processes throughout the body. In this study, we investigated the role of acrolein, a highly reactive aldehyde that is ubiquitously present in the environment and produced endogenously at sites of inflammation, in mediating PMN-mediated degradation of collagen facilitating proline-glycine-proline (PGP) production. We treated peripheral blood neutrophils with acrolein and analyzed cell supernatants and lysates for matrix metalloproteinase-9 (MMP-9) and prolyl endopeptidase (PE), assessed their ability to break down collagen and release PGP, and assayed for the presence of leukotriene A4 hydrolase (LTA4H) and its ability to degrade PGP. Acrolein treatment induced elevated production and functionality of collagen-degrading enzymes and generation of PGP fragments. Meanwhile, LTA4H levels and triaminopeptidase activity declined with increasing concentrations of acrolein thereby sparing PGP from enzymatic destruction. These findings suggest that acrolein exacerbates the acute inflammatory response mediated by neutrophils and sets the stage for chronic pulmonary and systemic inflammation.

Indexed as

AcroleinAminopeptidasesChronic DiseaseDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDose-Response Relationship, DrugHumansInflammationLeukotriene A4Matrix Metalloproteinase 9NeutrophilsOligopeptidesProlineProlyl OligopeptidasesSerine EndopeptidasesAcroleinAminopeptidasesDipeptidyl-Peptidases and Tripeptidyl-PeptidasesLeukotriene A4Matrix Metalloproteinase 9MMP9 protein, humanOligopeptidesPREPL protein, humanProlineprolyl-glycyl-prolineProlyl OligopeptidasesSerine Endopeptidasestripeptide aminopeptidaseacroleinchronic obstructive pulmonary diseaseinflammationneutrophils

Identifiers

PMID26208604
OpenAlexW1449204388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.