ArticleDiabetologia2015
Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study.
Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Type 2 Diabetes: How Much of an Autoimmune Disease?Frontiers in endocrinology · 2019Pooled it
- Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta-Analysis of 7 646 267 Participants From 135 Studies.Journal of the American Heart Association · 2018Pooled it
- Lifestyle and environmental risk factors for adult-onset autoimmune diabetes: current evidence and future directions.Diabetologia · 2026Review
- Using human genetics to understand the epidemiological association between child obesity at different ages and MASLD.International journal of surgery (London, England) · 2026Article
- Nutritional status of Vietnamese infants assessed by Fenton growth chart and related factors: A cross-sectional study.Pediatric investigation · 2023Article
- Birthweight, BMI in adulthood and latent autoimmune diabetes in adults: a Mendelian randomisation study.Diabetologia · 2022Article
- Lifestyle or Environmental Influences and Their Interaction With Genetic Susceptibility on the Risk of LADA.Frontiers in endocrinology · 2022Review
- Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes.Clinical and experimental immunology · 2019Article
- Birthweight correlates with later metabolic abnormalities in Chinese patients with maturity-onset diabetes of the young type 2.Endocrine · 2019Article
- Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared to Type 2 Diabetes.Frontiers in physiology · 2019Review
- Increased seroreactivity to proinsulin and homologous mycobacterial peptides in latent autoimmune diabetes in adults.PloS one · 2017Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisOur aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes.
methodsWe used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes.
resultsLow birthweight increased the risk of LADA as well as the risk of type 2 diabetes; OR per kg reduction was estimated as 1.52 (95% CI 1.12, 2.08) and 1.58 (1.23, 2.04), respectively. The OR for participants weighing <3 kg compared with ≥4 kg at birth was estimated as 2.38 (1.23, 4.60) for LADA and 2.37 (1.37, 4.10) for type 2 diabetes. A combination of low birthweight (<3 kg) and current overweight (BMI ≥ 25) further augmented the risk: LADA, OR 3.26 (1.69, 6.29); and type 2 diabetes, OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. CONCLUSIONS/
interpretationOur results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes.
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