Evidence map›Paper›PMID 26208586›Full record

SynthesisPathology oncology research : POR2016

Associations of Polymorphisms in mir-196a2, mir-146a and mir-149 with Colorectal Cancer Risk: A Meta-Analysis.

Liping Xu, Wenru Tang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Pathology oncology research : POR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Association ofBiomedicines · 2023
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Genetic variationOncoTargets and therapy · 2016
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Liping XuLaboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, 650500, Kunming, Yunnan, China.
Wenru TangLaboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, 650500, Kunming, Yunnan, China. 531081047@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are non-coding RNAs which act as tumor suppressors or oncogenes. And single nucleotide polymorphism (SNP) in miRNA regions is one type of genetic variations in human genome. Various studies have investigated the associations of miRNAs SNP and kinds of cancers. In this article, we searched eligible studies to explore the relationships between mir-196a2 /mir-146a /mir-149 polymorphisms and colorectal cancer (CRC). A literature search of PubMed, Web of Science and ScienceDirect was conducted to identify all relevant studies. Three genetic models with pooled ratio and 95% confidence interval were used to evaluate the associations. We found that mir-196a2 polymorphism was significantly associated with CRC in Asian group (additive model: OR = 1.197, 95%CI 1.084 ~ 1.32, P < 0.001; dominant model: OR = 1.247, 95%CI 1.065 ~ 1.46, P = 0.006; recessive model: OR = 1.298, 95%CI 1.101 ~ 1.531, P = 0.002). And no associations were observed between SNPs of mir-146a, mir-149 and CRC in three genetic models. We also found CRC risk was not associated with mir-146a and mir-149 polymorphisms in population subgroup analysis. The current meta-analysis suggests that mir-196a2 polymorphism is associated with CRC, especially in Asian group. While, no associations have been found between mir-146a /mir-149 polymorphisms and CRC.

Indexed as

Colorectal NeoplasmsGenetic Predisposition to DiseaseHumansMicroRNAsPolymorphism, Single NucleotideRisk FactorsMicroRNAsMIRN146 microRNA, humanMIRN149 microRNA, humanMIRN196 microRNA, humanCRCmir-146amir-149mir-196a2SNP

Identifiers

PMID26208586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.