ArticleJournal of pediatric endocrinology & metabolism : JPEM2015
Neonatal diabetes in Ukraine: incidence, genetics, clinical phenotype and treatment.
Article in Journal of pediatric endocrinology & metabolism : JPEM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees.Acta paediatrica (Oslo, Norway : 1992) · 2022Pooled it
- Clinical and Genetic Characteristics ofJournal of diabetes research · 2021Pooled it
- Low-level mosaic variants causing the pancreatic disease congenital hyperinsulinism can be detected from blood DNA.EBioMedicine · 2026Article
- Case Report: When genetic diagnosis comes late: lessons from a DEND syndrome patient successfully transitioned to sulfonylurea.Frontiers in clinical diabetes and healthcare · 2025Article
- Incidence, Phenotypes, and Genotypes of Neonatal Diabetes: A 16-Year Experience. The Rare Genetic Etiologies of Neonatal Diabetes Are Common in Sudan.Pediatric diabetes · 2024Article
- Neonatal and early-onset diabetes in Ukraine: Atypical features and mortality.Diabetic medicine : a journal of the British Diabetic Association · 2023Article
- A Review of the Biosynthesis and Structural Implications of Insulin Gene Mutations Linked to Human Disease.Cells · 2023Review
- The Mutation Spectrum of Rare Variants in the Gene of Adenosine Triphosphate (ATP)-Binding Cassette Subfamily C Member 8 in Patients with a MODY Phenotype in Western Siberia.Journal of personalized medicine · 2023Article
- Genetic Etiology of Neonatal Diabetes Mellitus in Vietnamese Infants and Characteristics of Those WithFrontiers in endocrinology · 2022Article
- Identification of GCK-maturity-onset diabetes of the young in cases of neonatal hyperglycemia: A case series and review of clinical features.Pediatric diabetes · 2021Article
- Molecular Genetics, Clinical Characteristics, and Treatment Outcomes of KFrontiers in endocrinology · 2021Article
- Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells.Diabetologia · 2020Article
- Genetic Spectrum of Neonatal Diabetes.Balkan journal of medical genetics : BJMG · 2020Article
- Clinical features and partial proportional molecular genetics in neonatal diabetes mellitus: a retrospective analysis in southwestern China.Endocrine · 2020Article
- New insights into KNature reviews. Endocrinology · 2020Review
- Congenital forms of diabetes: the beta-cell and beyond.Current opinion in genetics & development · 2018Review
- Sulfonylurea for the treatment of neonatal diabetes owing to KOncotarget · 2017Article
- Incidence, prevalence and genetic determinants of neonatal diabetes mellitus: a systematic review and meta-analysis protocol.Systematic reviews · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundNeonatal diabetes has not been previously studied in Ukraine. We investigated the genetic etiology in patients with onset of diabetes during the first 9 months of life.
methodsWe established a Pediatric Diabetes Register to identify patients diagnosed with diabetes before 9 months of age. Genetic testing was undertaken for 42 patients with permanent or transient diabetes diagnosed within the first 6 months of life (n=22) or permanent diabetes diagnosed between 6 and 9 months (n=20).
resultsWe determined the genetic etiology in 23 of 42 (55%) patients; 86% of the patients diagnosed before 6 months and 20% diagnosed between 6 and 9 months. The incidence of neonatal diabetes in Ukraine was calculated to be 1 in 126,397 live births.
conclusionsGenetic testing for patients identified through the Ukrainian Pediatric Diabetes Register identified KCNJ11 and ABCC8 mutations as the most common cause (52%) of neonatal diabetes. Transfer to sulfonylureas improved glycemic control in all 11 patients.
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