ArticleeLife2015
Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
119 citing papers in PubMed.
- Hunger recruits a parallel circuit encoding alcohol reward.Current biology : CB · 2026Article
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
- A predator-derived odor specifically triggers avoidance in gregarious mated female Locusta migratoria.Pest management science · 2026Article
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- Whole-brain, all-optical interrogation of neuronal dynamics underlying gut and vascular interoception in zebrafish.Nature communications · 2026Article
- Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system.Journal of neurophysiology · 2026Article
- Two neuropeptides that promote blood feeding ineLife · 2026Article
- Advances and Prospects in Odour-based Management of Filth Flies.Journal of chemical ecology · 2026Review
- Nutrient Deprivation inInternational journal of molecular sciences · 2026Article
- Global Profiling of Post-Translationally Modified Crustacean Neuropeptidome Trends Affiliated with Feeding Activity.Journal of the American Society for Mass Spectrometry · 2026Article
- Unexpected Evolutionary Divergence of Tachykinin-Positive Neurons Innervating the Central Complex in Hexapods.The Journal of comparative neurology · 2026Article
- Insulin signaling engages divergent transcriptional mechanisms in neural and metabolic tissues.BMC molecular and cell biology · 2026Article
- Transcriptome Analysis of the Brain and Gnathal Ganglion Reveals Feeding-Mediated Genes inBiomolecules · 2026Article
- Article
- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- Shaping of olfactory responses by taste in a new assay for operant learning in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
- Hunger Recruits a Parallel Circuit Encoding Alcohol Reward.bioRxiv : the preprint server for biology · 2025Article
- Article
- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
The internal state of an organism influences its perception of attractive or aversive stimuli and thus promotes adaptive behaviors that increase its likelihood of survival. The mechanisms underlying these perceptual shifts are critical to our understanding of how neural circuits support animal cognition and behavior. Starved flies exhibit enhanced sensitivity to attractive odors and reduced sensitivity to aversive odors. Here, we show that a functional remodeling of the olfactory map is mediated by two parallel neuromodulatory systems that act in opposing directions on olfactory attraction and aversion at the level of the first synapse. Short neuropeptide F sensitizes an antennal lobe glomerulus wired for attraction, while tachykinin (DTK) suppresses activity of a glomerulus wired for aversion. Thus we show parallel neuromodulatory systems functionally reconfigure early olfactory processing to optimize detection of nutrients at the risk of ignoring potentially toxic food resources.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.