Evidence map›Paper›PMID 26207909›Full record

ArticlePloS one2015

Elevated Levels of Serum Tumor Markers CEA and CA15-3 Are Prognostic Parameters for Different Molecular Subtypes of Breast Cancer.

Yingbo Shao, Xianfu Sun, Yaning He, Chaojun Liu, Hui Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yingbo ShaoDepartment of Breast oncology, The Affiliated Cancer Hospital Of Zhengzhou University, Zhengzhou, China; He'nan Province Tumor Hospital, Zhengzhou, China.
Xianfu SunDepartment of Breast oncology, The Affiliated Cancer Hospital Of Zhengzhou University, Zhengzhou, China; He'nan Province Tumor Hospital, Zhengzhou, China.
Yaning HeDepartment of Breast oncology, The Affiliated Cancer Hospital Of Zhengzhou University, Zhengzhou, China; He'nan Province Tumor Hospital, Zhengzhou, China.
Chaojun LiuDepartment of Breast oncology, The Affiliated Cancer Hospital Of Zhengzhou University, Zhengzhou, China; He'nan Province Tumor Hospital, Zhengzhou, China.
Hui LiuDepartment of Breast oncology, The Affiliated Cancer Hospital Of Zhengzhou University, Zhengzhou, China; He'nan Province Tumor Hospital, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsThe utility of measuring carcinoembryonic antigen(CEA) and cancer antigen 15-3 (CA15-3) levels in patients with breast cancer remains controversial. The present study aims to investigate the prognostic value of preoperative serum CEA and CA15-3 levels in breast cancer patients.

methodsSerum preoperative CEA and CA 15-3 concentration levels were measured in a total of 432 breast cancer patients. The association of tumor markers levels with clinicopathological parameters and outcomes were analyzed.

resultsElevated serum levels of CEA and CA15-3 were identified in 47 (10.9%) and 60(13.9%) patients, respectively. Larger tumor size, advanced axillary lymph nodal and TNM stage exhibited higher proportion of elevated CEA and CA15-3 levels. The elevation of CEA levels was significantly greater in patients with HER2 positive tumors, and the elevation of CA15-3 levels was significantly greater in ER negative breast patients. Univariate and multivariate Cox's regression analysis revealed that elevated preoperative CEA and CA 15-3 levels were independent prognostic factors for DFS and OS. When considering the combination of both markers levels, patients with both elevated markers presented the worst survival. Independent prognostic significance of elevated preoperative serum CEA and CA15-3 levels were reconfirmed in Luminal B breast cancer.

conclusionsPreoperative serum levels of CEA and CA15-3 are independent prognostic parameters for breast cancer.

Indexed as

AdolescentAdultAgedBiomarkers, TumorBreast NeoplasmsCarcinoembryonic AntigenErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedMucin-1Neoplasm StagingPrognosisYoung AdultBiomarkers, TumorCarcinoembryonic AntigenERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesMucin-1

Identifiers

PMID26207909
PMCPMC4514648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.