ArticlePloS one2015
HPV Infection and Cervical Screening in Socially Isolated Indigenous Women Inhabitants of the Amazonian Rainforest.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Prevalence of human papillomavirus (HPV) in Brazil: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Racial inequities in cervical cancer mortality and the role of the Bolsa Família conditional cash transfer programme: results from the 100 Million Brazilian Cohort.Lancet regional health. Americas · 2026Article
- Barriers to Accessing Cervical Cancer Screening and Treatment in the Amazon Region-A Systematic Review.Journal of clinical medicine · 2026Review
- The epidemiology of cervical cancer among indigenous women living in Latin America: A systematic review.Preventive medicine reports · 2025Review
- Article
- Addressing the burden of cervical cancer for Indigenous women in Latin America and the Caribbean: a call for action.Frontiers in public health · 2024Review
- Article
- High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Cervical cancer screening in Brazilian Amazon Indigenous women: Towards the intensification of public policies for prevention.PloS one · 2023Article
- Cervical HPV infection in Yueyang, China: a cross-sectional study of 125,604 women from 2019 to 2022.Frontiers in public health · 2023Article
- Incidence and mortality of cervical cancer in French Guiana: Temporal and spatial trends.Public health in practice (Oxford, England) · 2021Article
- Review
- E6/E7 Sequence Diversity of High-Risk Human Papillomaviruses in Two Geographically Isolated Populations of French Guiana.Microorganisms · 2020Article
- HIV Modifies the Effect of Tobacco Smoking on Oral Human Papillomavirus Infection.The Journal of infectious diseases · 2020Article
- The prevalence and genotype distribution of human papillomaviruses among women in Taizhou, China.Medicine · 2019Article
- Non-human Primate Papillomaviruses Share Similar Evolutionary Histories and Niche Adaptation as the Human Counterparts.Frontiers in microbiology · 2019Article
- Niche adaptation and viral transmission of human papillomaviruses from archaic hominins to modern humans.PLoS pathogens · 2018Article
- Cervico-vaginal self-collection in HIV-infected and uninfected women from Tapajós region, Amazon, Brazil: High acceptability, hrHPV diversity and risk factors.Gynecologic oncology · 2018Article
- Oral Alpha, Beta, and Gamma HPV Types and Risk of Incident Esophageal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Prevalence and Epidemiologic Profile of Oral Infection with Alpha, Beta, and Gamma Papillomaviruses in an Asian Chinese Population.The Journal of infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIndigenous women from the Amazon regions have some of the highest rates of cervical cancer in the world. This study evaluated cervical cytology and human papillomavirus (HPV) in native women that differ by lifestyle and interaction with western society. Yanomami women are isolated deep in the Amazon with a hunter/gatherer lifestyle. Macuxi and Wapishana women live in proximity to western society.
methodsTo select a representative group of women from each district, random cluster sampling was used, considering each registered village as a cluster. Cervical samples were collected for cytology and HPV detection and typing by PCR amplification and next generation sequencing. The study was approved by the National IRB and by tribal leaders.
results664 native women were enrolled from 13 indigenous villages (76% participation rate). Yanomami women had higher rates of abnormal cytology (5.1% vs. 1.8%, p = 0.04) and prevalent HR-HPV (34.1% vs. 19.2%, p<0.001). Yanomami women >35 y of age were significantly more likely to have HR-HPV, whereas women ≤ 35 y did not significantly differ between groups. Prevalence of HPV was significantly different amongst geographically clustered Yanomami women (p<0.004). The most prevalent HPV types in the entire group were HPV31 (8.7%), HPV16 (5.9%) and HPV18 (4.4%).
conclusionIsolated endogenous Yanomami women were more likely to be HPV+ and rates increased with age. Study of HPV in isolated hunter-gather peoples suggests that long-term persistence is a characteristic of prehistoric humans and patterns reflecting decreased prevalence with age in western society represents recent change. These studies have implications for cervical cancer prevention and viral-host relationships.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.