ArticleMagnetic resonance in medicine2016
Surface-to-volume ratio mapping of tumor microstructure using oscillating gradient diffusion weighted imaging.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 62 citations in OpenAlex.
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- Non-Invasive Detection of Prostate Cancer with Novel Time-Dependent Diffusion MRI and AI-Enhanced Quantitative Radiological Interpretation: PROS-TD-AI.Journal of imaging · 2026Article
- Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025Review
- Diffusion time effects over the adult lifespan indicates persistent zone-specific microstructural alterations in the human prostate with aging.Magnetic resonance in medicine · 2025Article
- Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: Overfitting or meaningful parameter?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Assessing tumor microstructure with time-dependent diffusion imaging: Considerations and feasibility on clinical MRI and MRI-Linac.Medical physics · 2025Article
- In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI.Science advances · 2024Article
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- Time-dependent diffusion MRI using multiple stimulated echoes.Magnetic resonance in medicine · 2023Article
- Time-dependent diffusivity and kurtosis in phantoms and patients with head and neck cancer.Magnetic resonance in medicine · 2023Article
- Diffusion MRI with pulsed and free gradient waveforms: Effects of restricted diffusion and exchange.NMR in biomedicine · 2023Article
- Article
- Quantitative magnetic resonance imaging and tumor forecasting of breast cancer patients in the community setting.Nature protocols · 2021Review
- Measurement of cellular-interstitial water exchange time in tumors based on diffusion-time-dependent diffusional kurtosis imaging.NMR in biomedicine · 2021Article
- The present and the future of microstructure MRI: From a paradigm shift to normal science.Journal of neuroscience methods · 2021Review
- Diffusion-time dependence of diffusional kurtosis in the mouse brain.Magnetic resonance in medicine · 2020Article
- Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI.PloS one · 2020Article
- Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation.NMR in biomedicine · 2019Review
- What dominates the time dependence of diffusion transverse to axons: Intra- or extra-axonal water?NeuroImage · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo disentangle the free diffusivity (D0 ) and cellular membrane restrictions, by means of their surface-to-volume ratio (S/V), using the frequency-dependence of the diffusion coefficient D(ω), measured in brain tumors in the short diffusion-time regime using oscillating gradients (OGSE).
methodsIn vivo and ex vivo OGSE experiments were performed on mice bearing the GL261 murine glioma model (n = 10) to identify the relevant time/frequency (t/ω) domain where D(ω) linearly decreases with ω(-1/2) . Parametric maps (S/V, D0 ) are compared with conventional DWI metrics. The impact of frequency range and temperature (20°C versus 37°C) on S/V and D0 is investigated ex vivo.
resultsThe validity of the short diffusion-time regime is demonstrated in vivo and ex vivo. Ex vivo measurements confirm that the purely geometric restrictions embodied in S/V are independent from temperature and frequency range, while the temperature dependence of the free diffusivity D0 is similar to that of pure water.
conclusionOur results suggest that D(ω) in the short diffusion-time regime can be used to uncouple the purely geometric restriction effect, such as S/V, from the intrinsic medium diffusivity properties, and provides a nonempirical and objective way to interpret frequency/time-dependent diffusion changes in tumors in terms of objective biophysical tissue parameters. Magn Reson Med 76:237-247, 2016. © 2015 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.