Evidence map›Paper›PMID 26207230›Full record

ReviewAnnals of translational medicine2015

Comparison of different stimulation protocols used in in vitro fertilization: a review.

Deekshya Shrestha, Xiaolin La, Huai L Feng

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06378268 (Effectiveness of Progestin-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol for Ovarian Stimulation in IVF), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06378268 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Effectiveness of Progestin-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol for Ovarian Stimulation in IVF: a Randomized Clinical Trial

TypeinterventionalSponsorMỹ Đức HospitalRan2024 to 2026Enrolled626ConditionsProgestins Primed Ovarian StimulationArmsDydrogesterone 10 mg, Cetrorelix 0.25 mg
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
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  7. Overview of ADPKD in Pregnancy.Kidney international reports · 2025
    Review
  8. Article
  9. Article
  10. Article
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  12. One size does not fit all: the personal nature of completed embryo donation.Journal of assisted reproduction and genetics · 2024
    Article
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  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Deekshya Shrestha1 Department of Reproduction, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China ; 2 The New Fertility Center, New York Hospital Queens Affiliated Weill Medical College of Cornell University, New York, NY, USA.
Xiaolin La1 Department of Reproduction, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China ; 2 The New Fertility Center, New York Hospital Queens Affiliated Weill Medical College of Cornell University, New York, NY, USA.
Huai L Feng1 Department of Reproduction, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China ; 2 The New Fertility Center, New York Hospital Queens Affiliated Weill Medical College of Cornell University, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility is one of the major medical problems in the western world caused by genetic or epigenetic factors, or both, which has led to continuous research and advancements in the field of assisted reproductive technology (ART). Many stimulation protocols are available for controlled ovarian hyperstimulation (COH) in in vitro fertilization (IVF). This review compares the agonist long protocol, antagonist protocol and minimal stimulation protocol. Gonadotropin-releasing hormone (GnRH) antagonist and minimal stimulation protocol has shorter duration of treatment and less gonadotropin use. GnRH agonist long protocol is better in folliculogenesis and pregnancy rate, which is the imperative goal of COH. Despite its costly and lengthy approach, GnRH agonist long protocol has delivered satisfactory results in most women. On the other hand, patients with poor ovarian reserve may have greater advantage when considering minimal stimulation protocol. Evidently, it is crucial to have a larger scale studies with more focused comparisons, which take into account the differences in patients' response criteria and additional confounding variables (age, BMI, previous IVF outcomes etc.), in order to reach to a more definite conclusions.

Indexed as

epigeneticgeneticsgonadotropinIn vitro fertilization (IVF)stimulation

Identifiers

PMID26207230
PMCPMC4486909

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.