ReviewTranslational lung cancer research2015
Chitinase-3-like-1/YKL-40 as marker of circulating tumor cells.
Review in Translational lung cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture.Arteriosclerosis, thrombosis, and vascular biology · 2016Trial
- Structural optimization of CHI3L1 inhibitors with improved pharmacokinetics and functional activity in 3D glioblastoma models.Journal of enzyme inhibition and medicinal chemistry · 2026Article
- Pan-cancer bone metastasis atlas at single-cell resolution identifies a distinct tumor-associated macrophage subset for mediating Denosumab-induced immunosensitization in lung cancer bone metastasis.International journal of biological sciences · 2026Article
- Future Perspectives and Conclusions from Animal Models of CHI3L1-Related Inflammation-Associated Cancer.Cells · 2025Review
- Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer.Experimental & molecular medicine · 2024Review
- Possible Prognostic Potential of RANKL and OPG in Metastatic Breast Cancer Egyptian Females.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- A robust strategy for proteomic identification of biomarkers of invasive phenotype complexed with extracellular heat shock proteins.Cell stress & chaperones · 2019Article
- Circulating tumor cell interactions with macrophages: implications for biology and treatment.Translational lung cancer research · 2017Review
- RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis.Scientific reports · 2016Article
- Small cell lung cancer: Recruitment of macrophages by circulating tumor cells.Oncoimmunology · 2016Article
- Second-line therapy for small cell lung cancer: exploring the potential role of circulating tumor cells.Translational lung cancer research · 2016Article
- Smoking, inflammation and small cell lung cancer: recent developments.Wiener medizinische Wochenschrift (1946) · 2015Review
- How to target small cell lung cancer.Oncoscience · 2015Article
- Receptor tyrosine kinase expression of circulating tumor cells in small cell lung cancer.Oncoscience · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ex vivo expansion of circulating tumor cells (CTCs) of small cell lung cancer (SCLC) patients enabled systematic screening of secreted cytokines. Permanent CTC cultures of different patients shared secretion of chitinase-3-like-1 (CHI3L1)/YKL-40, known to be upregulated in a range of tumor entities and to be associated with increased metastasis and decreased survival. This protein lacks enzymatic activity and its mechanism of promoting tumor dissemination has not been resolved. Results from SCLC CTC cultures suggest CHI3L1 as marker and important effector of tumor cell dissemination in the peripheral blood. Furthermore, this protein may link chronic inflammation of the lung, chronic obstructive pulmonary disease (COPD) and lung cancer.
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