Evidence map›Paper›PMID 26207160›Full record

ArticleThe World Allergy Organization journal2015

Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.

Gennaro D'Amato, Stephen T Holgate, Ruby Pawankar, Dennis K Ledford, Lorenzo Cecchi, Mona Al-Ahmad, Fatma Al-Enezi, Saleh Al-Muhsen, Ignacio Ansotegui, Carlos E Baena-Cagnani and 30 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04902989 (Association Between Environmental Pollutants and Their Effects on Respiratory), which is not on this map. Cited by 177 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 10 pooled it
26.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04902989 unknown statusnot on this mapstarted 2021, after this paper: background citation

Association Between Environmental Pollutants and Their Effects on Respiratory

TypeobservationalSponsorCindy Elizabeth de Lira-QuezadaRan2021 to 2022Enrolled93ConditionsAllergic Rhinitis, Allergic Asthma, Pollution, ExposureArmspollutants and pollen
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 10 syntheses or guidelines pooled it, 581 citations in OpenAlex.

  1. Pooled it
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  6. Extreme weather and asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
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  15. Relative contributions of meteorological factors and atmospheric pollutants to childhood adenoid hypertrophy: A time-series study in Chongqing, China.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
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  17. Unmasking the Impact of Air Pollution on Allergic Rhinitis.Clinical reviews in allergy & immunology · 2026
    Review
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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 23 countries.

Gennaro D'AmatoDepartment of Respiratory Diseases, Division of Pneumology and Allergology, High Specialty Hospital "A. Cardarelli" Napoli, Italy, University of Naples Medical School, Via Rione Sirignano, 10, 80121 Napoli, Italy.
Stephen T HolgateSouthampton General Hospital, Clinical and Experimental Sciences, University of Southampton, Hampshire, UK.
Ruby PawankarDepartment of Pediatrics, Nippon Medical School, Tokyo, Japan.
Dennis K LedfordMorsani College of Medicine, University of South Florida, Tampa, Florida.
Lorenzo CecchiInterdepartmental Centre of Bioclimatology, University of Florence Allergy and Clinical Immunology Section, Azienda Sanitaria di Prato, Italy.
Mona Al-AhmadDepartment of Allergy, Al-Rashid Center, Ministry of Health, Khobar, Kuwait.
Fatma Al-EneziAl-Rashid Allergy and Respiratory Center, Khobar, Kuwait.
Saleh Al-MuhsenDepartment of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ignacio AnsoteguiDepartment of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain.
Carlos E Baena-CagnaniCentre for Research in Respiratory Medicine, Faculty of Medicine, Catholic University of Córdoba, Córdoba, Argentina.
David J BakerEmeritus Consultant Anaesthesiologist, SAMU de Paris, Hôpital Necker - Enfants Malades, Paris, France.
Hasan BayramDepartment of Chest Diseases, Respiratory Research Laboratory, Allergy Division, School of Medicine, University of Gaziantep, Şehitkamil/Gaziantep, 27310 Turkey.
Karl Christian BergmannAllergy-Centrum-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Louis-Philippe BouletQuebec Heart and Lung Institute, Laval University, 2725 chemin Sainte-Foy, Quebec City, G1V 4G5 Canada.
Jeroen T M ButersZAUM - Center of Allergy and Environment, Helmholtz Zentrum München/Technische Universität München, Munich, Germany.
Maria D'AmatoUniversity of Naples, Institute of Respiratory Diseases, Naples, Italy.
Sofia DorsanoWorld Allergy Organization, Milwaukee, Wisconsin United States.
Jeroen DouwesCentre for Public Health Research, Massey University, Wellington, New Zealand.
Sarah Elise FinlayConsultant in Emergency Medicine, Chelsea and Westminster Hospital, London, UK.
Donata GarrasiDevelopment Assistance Committee, Organisation of Economic Cooperation and Development, Paris, France.
Maximiliano GómezAsthma & Allergy Unit, Hospital San Bernardo, Salta, Argentina.
Tari HaahtelaSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
Rabih HalwaniPrince Naif Center for Immunology Research, College of Medicine, King Saud University, P.O.Box 2925, Postal Code 11461 Riyadh, Saudi Arabia.
Youssouf HassaniEpidemiology of Respiratory and Allergic Disease Department, UMR-S, Institute Pierre Louis of Epidemiology and Public Health, INSERM Medical School Saint-Antoine, UPMC Sorbonne Universités, Paris, France.
Basam MahboubUniversity of Sharjah, and, Rashid Hospital DHA, Abu Dhabi, United Arab Emirates.
Guy MarksSouth Western Sydney Clinical School, UNSW, Australia and Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia.
Paola MichelozziDipartimento Epidemiologia Regione Lazio, UOC Epidemiologia Ambientale, Roma, Italy.
Marcello MontagniDepartment of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43100 Parma, Italy.
Carlos NunesCenter of Allergy of Algarve, Hospital Particular do Algarve, Particular do Algarve, Brasil.
Jay Jae-Won OhDepartment of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.
Todor A PopovClinic of Allergy and Asthma, Medical University in Sofia, Sofia, Bulgaria.
Jay PortnoyChildren's Mercy Hospitals & Clinics, Kansas City, Missouri USA.
Erminia RidoloDepartment of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43100 Parma, Italy.
Nelson RosárioDivision of Pediatric Respiratory Medicine, Hospital de Clínicas, Federal University of Parana, Rua Tte. João Gomes da Silva 226, 80810-100 Curitiba, PR Brazil.
Menachem RottemAllergy Asthma and Immunology, Emek Medical Center, Afula, and the Rappaport Faculty of Medicine Technion, Israel Institute of Technology, Haifa, Israel.
Mario Sánchez-BorgesClinica El Avila, Caracas, Venezuela.
Elopy SibandaAsthma, Allergy and Immune Dysfunction Clinic, Harare, Zimbabwe.
Juan José Sienra-MongeAllergy and Immunology Department, Hospital Infantil de México Federico Gómez, SSA, México City, Mexico.
Carolina VitaleUniversity of Naples, Institute of Respiratory Diseases, Naples, Italy.
Isabella Annesi-MaesanoEpidemiology of Respiratory and Allergic Disease Department (EPAR), Institute Pierre Louis of Epidemiology and Public Health, UMR-S 1136, INSERM, Paris, France ; UPMC, Sorbonne Universités, Medical School Saint-Antoine, 803-804-806, 8 etage/Floor 27, Rue Chaligny, CEDEX 12, 75571 Paris, France.
King Saud University · SASorbonne Université · FRUniversity of Naples Federico II · ITUniversity of Parma · ITAlgarve Biomedical Center · PTCharité - Universitätsmedizin Berlin · DEChelsea and Westminster Hospital · GBChildren's Mercy Hospital · USEmek Medical Center · ILGaziantep University · TRHanyang University · KRHelsinki University Hospital · FIHôpital Necker-Enfants Malades · FRHospital Clínico Universitario de Caracas · VEHospital Infantil de México Federico Gómez · MXHospital Quirónsalud Barcelona · ESMassey University · NZMedical University of Sofia · BGMinistry of Health · KWNippon Medical School · JP

Funding

Medical Research Council G0800766
6 · The paper itself

Abstract

The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions and motor vehicles, the rising trend can only be explained by gross changes in the environments where we live. The world economy has been transformed over the last 25 years with developing countries being at the core of these changes. Around the planet, in both developed and developing countries, environments are undergoing profound changes. Many of these changes are considered to have negative effects on respiratory health and to enhance the frequency and severity of respiratory diseases such as asthma in the general population. Increased concentrations of greenhouse gases, and especially carbon dioxide (CO2), in the atmosphere have already warmed the planet substantially, causing more severe and prolonged heat waves, variability in temperature, increased air pollution, forest fires, droughts, and floods - all of which can put the respiratory health of the public at risk. These changes in climate and air quality have a measurable impact not only on the morbidity but also the mortality of patients with asthma and other respiratory diseases. The massive increase in emissions of air pollutants due to economic and industrial growth in the last century has made air quality an environmental problem of the first order in a large number of regions of the world. A body of evidence suggests that major changes to our world are occurring and involve the atmosphere and its associated climate. These changes, including global warming induced by human activity, have an impact on the biosphere, biodiversity, and the human environment. Mitigating this huge health impact and reversing the effects of these changes are major challenges. This statement of the World Allergy Organization (WAO) raises the importance of this health hazard and highlights the facts on climate-related health impacts, including: deaths and acute morbidity due to heat waves and extreme meteorological events; increased frequency of acute cardio-respiratory events due to higher concentrations of ground level ozone; changes in the frequency of respiratory diseases due to trans-boundary particle pollution; altered spatial and temporal distribution of allergens (pollens, molds, and mites); and some infectious disease vectors. According to this report, these impacts will not only affect those with current asthma but also increase the incidence and prevalence of allergic respiratory conditions and of asthma. The effects of climate change on respiratory allergy are still not well defined, and more studies addressing this topic are needed. Global warming is expected to affect the start, duration, and intensity of the pollen season on the one hand, and the rate of asthma exacerbations due to air pollution, respiratory infections, and/or cold air inhalation, and other conditions on the other hand.

Identifiers

PMID26207160
PMCPMC4499913
OpenAlexW1952843992

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.