Evidence map›Paper›PMID 26207106›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2015

The Warburg effect: a balance of flux analysis.

B Vaitheesvaran, J Xu, J Yee, Lu Q-Y, V L Go, G G Xiao, W N Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 57 citations in OpenAlex.

  1. Biomolecules · 2026
    Article
  2. Review
  3. Tumor-Associated Macrophage in Breast Tumor Microenvironment.International journal of molecular sciences · 2025
    Review
  4. Significance of Malic Enzyme 1 in Cancer: A Review.Current issues in molecular biology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Serum and MuscleNutrients · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Molecules (Basel, Switzerland) · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

B VaitheesvaranDepartment of Medicine, Diabetes Center, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine Diabetes Center, Bronx, New York, USA.
J XuDepartment of Pathology, University of Southern California, Los Angeles, Caligornia, USA.
J YeeDepartment of Pediatrics, Division of Endocrinology and Metabolism, University of California, Los Angeles, California, USA.
Lu Q-YDepartment of Medicine, University of California, Los Angeles, CA, USA.
V L GoDepartment of Medicine, University of California, Los Angeles, CA, USA.
G G XiaoFunctional Genomics/Proteomics Laboratories Creighton University medical Center, Nebraska, and School of Pharmaceutical Science and Technology at Dalian University of Technology, Dalian, China.
W N LeeLA Biomedical Research Institute, Torrance, CA, USA and Department of Pediatrics, Division of Endocrinology and Metabolism, University of California, Los Angeles, California USA.
University of California, Los Angeles · USAlbert Einstein College of Medicine · USCHI Health Creighton University Medical Center - Bergan Mercy · USThe Lundquist Institute · USUniversity of Southern California · US

Funding

Stem Cell-Based Therapies for Radiation-Induced Gastrointestinal Sydrome (RIGS)U19AI091175 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GUHA, CHANDAN · 2010 to 2014
$13.1M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL · 2012 to 2016
$6.2M
UCLA Center for Excellence in Pancreatic DiseasesP01AT003960 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HINES, OSCAR JOE · 2007 to 2011
$5.6M
Hepatic Insuling Action: Role of the Pentose CycleR01DK058132 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURLAND, IRWIN JACK · 2002 to 2011
$3.4M
VITAMIN/TRACE ELEMENT COREP01CA042710 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUISIS, A J · 1985 to 2001
$1.6M
NCCIH NIH HHS P01 AT003960NCI NIH HHS P01 CA042710NCI NIH HHS P01 CA163200NIAID NIH HHS U19 AI091175NIDDK NIH HHS R01 DK058132
6 · The paper itself

Abstract

Cancer metabolism is characterized by increased macromolecular syntheses through coordinated increases in energy and substrate metabolism. The observation that cancer cells produce lactate in an environment of oxygen sufficiency (aerobic glycolysis) is a central theme of cancer metabolism known as the Warburg effect. Aerobic glycolysis in cancer metabolism is accompanied by increased pentose cycle and anaplerotic activities producing energy and substrates for macromolecular synthesis. How these processes are coordinated is poorly understood. Recent advances have focused on molecular regulation of cancer metabolism by oncogenes and tumor suppressor genes which regulate numerous enzymatic steps of central glucose metabolism. In the past decade, new insights in cancer metabolism have emerged through the application of stable isotopes particularly from

Identifiers

PMID26207106
PMCPMC4507278
OpenAlexW2147882007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.