Evidence map›Paper›PMID 26207073›Full record

ArticleJournal of molecular structure2015

Structural basis for the antipolymer activity of Hb ζ

Martin K Safo, Tzu-Ping Ko, Eric R Schreiter, J Eric Russell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular structure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Hemoglobin: Structure, Function and Allostery.Sub-cellular biochemistry · 2020
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Martin K SafoInstitute for Structural Biology and Drug Discovery, and the Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298; msafo@vcu.edu.
Tzu-Ping KoInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; kotping@gate.sinica.edu.tw.
Eric R SchreiterHoward Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147; eric.schreiter@gmail.com.
J Eric RussellDivision of Hematology-Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104; jeruss@mail.med.upenn.edu.

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
REGULATION AND FUNCTION OF A HUMAN EMBRYONIC GLOBINR01HL061399 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RUSSELL, J ERIC · 1999 to 2012
$3.9M
Hemoglobin Modifiers for Sickle Cell Disease TherapyR01MD009124 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAFO, MARTIN K · 2014 to 2018
$2.1M
Nucleolin-mediated stabilization of human B-globin mRNAR01HL082754 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RUSSELL, J ERIC · 2007 to 2011
$2.0M
NCI NIH HHS P30 CA016059NHLBI NIH HHS R01 HL061399NHLBI NIH HHS R01 HL082754NIMHD NIH HHS R01 MD009124
6 · The paper itself

Abstract

The phenotypical severity of sickle-cell disease (SCD) can be mitigated by modifying mutant hemoglobin S (Hb S, Hb α

Indexed as

HemoglobinMutationPolymerizationSickle Cell DiseaseStructureTense State

Identifiers

PMID26207073
PMCPMC4507290

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.