Evidence map›Paper›PMID 26206872›Full record

ReviewThe European respiratory journal2015

A summary of the new GINA strategy: a roadmap to asthma control.

Helen K Reddel, Eric D Bateman, Allan Becker, Louis-Philippe Boulet, Alvaro A Cruz, Jeffrey M Drazen, Tari Haahtela, Suzanne S Hurd, Hiromasa Inoue, Johan C de Jongste and 10 more

2 registry-linked trialsAbstract readReview
In one paragraph

Review in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 283 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04166344 nacompletednot on this mapstarted 2021, after this paper: background citation

Effectiveness of a Web-based, Digital Health Platform Combining Social Care and Respiratory Coach Support to Improve Adherence to Treatment and Symptom Control in Children and Adolescents with Difficult-to-control Asthma

TypeinterventionalSponsorLovexair FoundationRan2021 to 2024Enrolled60ConditionsAsthma in ChildrenArmsHappyair Ecosystem
NCT04929626 phase1completednot on this mapstarted 2022, after this paper: background citation

Comparison of Doses of Nebulized Magnesium Sulphate as an Adjuvant Treatment With Salbutamol in Children With Status Asthmaticus

TypeinterventionalSponsorZiauddin UniversityRan2022 to 2022Enrolled126ConditionsStatus AsthmaticusArmsMagnesium Sulfate 500 mg/ml+ ventolin, Ventolin
3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.American journal of respiratory cell and molecular biology · 2025
    Pooled it
  2. Quality of life of primary caregivers by severity and control of children's asthma: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. A Systematic Review of the Effect of Physical Activity on Asthma Outcomes.The journal of allergy and clinical immunology. In practice · 2021
    Pooled it
  6. Pooled it
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  9. Trial
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  18. Circulating microRNAs Predict Longitudinal Asthma Control and Treatment Response.medRxiv : the preprint server for health sciences · 2026
    Article
  19. Article
  20. Stage-dependent interaction between circulating and tissue-resident memory CD4Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article

223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Helen K ReddelWoolcock Institute of Medical Research, University of Sydney, Sydney, Australia helen.reddel@sydney.edu.au.
Eric D BatemanUniversity of Cape Town Lung Institute, Cape Town, South Africa.
Allan BeckerUniversity of Manitoba, Winnipeg, MB, Canada.
Louis-Philippe BouletQuebec Heart and Lung Institute, Laval University, Québec City, QC, Canada.
Alvaro A CruzFederal University of Bahia, Salvador, Brazil.
Jeffrey M DrazenHarvard Medical School, Boston, MA, USA.
Tari HaahtelaHelsinki University Central Hospital, Helsinki, Finland.
Suzanne S HurdGlobal Initiative for Asthma, Vancouver, WA, USA.
Hiromasa InoueKagoshima University, Kagoshima, Japan.
Johan C de JongsteDept of Pediatrics, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Robert F LemanskeUniversity of Wisconsin, Madison, WI, USA.
Mark L LevyGeneral Practitioner, London, UK.
Paul M O'ByrneFirestone Institute of Respiratory Health, St. Joseph's Healthcare and McMaster University, Hamilton, ON, Canada.
Pierluigi PaggiaroUniversity of Pisa, Pisa, Italy.
Soren E PedersenPediatric Research Unit, University of Southern Denmark, Kolding Hospital, Kolding, Denmark.
Emilio PizzichiniUniversidade Federal de Santa Catarina, NUPAIVA Asthma Research Centre, Florianópolis, Brazil.
Manuel Soto-QuirozNational Childreńs Hospital, University of Costa Rica San Jose, San Jose, Costa Rica.
Stanley J SzeflerChildren's Hospital Colorado, Aurora, CO, USA.
Gary W K WongDept of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong.
J Mark FitzGeraldInstitute for Heart and Lung Health, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and annually updated a global strategy for asthma management and prevention that has formed the basis for many national guidelines. However, uptake of existing guidelines is poor. A major revision of the GINA report was published in 2014, and updated in 2015, reflecting an evolving understanding of heterogeneous airways disease, a broader evidence base, increasing interest in targeted treatment, and evidence about effective implementation approaches. During development of the report, the clinical utility of recommendations and strategies for their practical implementation were considered in parallel with the scientific evidence.This article provides a summary of key changes in the GINA report, and their rationale. The changes include a revised asthma definition; tools for assessing symptom control and risk factors for adverse outcomes; expanded indications for inhaled corticosteroid therapy; a framework for targeted treatment based on phenotype, modifiable risk factors, patient preference, and practical issues; optimisation of medication effectiveness by addressing inhaler technique and adherence; revised recommendations about written asthma action plans; diagnosis and initial treatment of the asthma-chronic obstructive pulmonary disease overlap syndrome; diagnosis in wheezing pre-school children; and updated strategies for adaptation and implementation of GINA recommendations.

Indexed as

Disease ManagementGlobal HealthPractice Guidelines as TopicAdministration, InhalationAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaFemaleForecastingHumansMalePulmonary Disease, Chronic ObstructiveSeverity of Illness IndexAdrenal Cortex HormonesAnti-Asthmatic Agents

Identifiers

PMID26206872
PMCPMC4554554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.