ArticleThe British journal of psychiatry : the journal of mental science2016
Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia.
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Article in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Nucleus Reuniens-Elicited Delta Oscillations Disable the Prefrontal Cortex in Schizophrenia.Cells · 2025Review
- Psychedelics and schizophrenia: a double-edged sword.Molecular psychiatry · 2025Review
- Estimating and detecting slow wave events in EEG.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Atypical cortical networks in children at high-genetic risk of psychiatric and neurodevelopmental disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Magnetoencephalography in Psychiatry: A Perspective on Translational Research and Applications.Advances in neurobiology · 2024Review
- The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview.Advances in neurobiology · 2024Review
- Electrophysiological Markers Predicting Antipsychotic Treatment Response in Patients with Schizophrenia: A Retrospective Study.Neuropsychiatric disease and treatment · 2024Article
- Capsaicin Changes the Pattern of Brain Rhythms in Sleeping Rats.Molecules (Basel, Switzerland) · 2023Article
- Assessment of electroencephalography modification by antipsychotic drugs in patients with schizophrenia spectrum disorders using frontier orbital theory: A preliminary study.Neuropsychopharmacology reports · 2023Article
- E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury.Lancet regional health. Americas · 2022Article
- Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.The American journal of psychiatry · 2021Review
- Sleep, sleep spindles, and cognitive functions in drug-naive patients with first-episode psychosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Sleep spindle and slow wave abnormalities in schizophrenia and other psychotic disorders: Recent findings and future directions.Schizophrenia research · 2020Article
- Magnetoencephalography for Schizophrenia.Neuroimaging clinics of North America · 2020Review
- Reduced parietal alpha power and psychotic symptoms: Test-retest reliability of resting-state magnetoencephalography in schizophrenia and healthy controls.Schizophrenia research · 2020Article
- Patient, interrupted: MEG oscillation dynamics reveal temporal dysconnectivity in schizophrenia.NeuroImage. Clinical · 2020Article
- Identifying auditory cortex encoding abnormalities in schizophrenia: The utility of low-frequency versus 40 Hz steady-state measures.Psychophysiology · 2018Article
- Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder.Translational psychiatry · 2018Review
- Evaluation of short interval cortical inhibition and intracortical facilitation from the dorsolateral prefrontal cortex in patients with schizophrenia.Scientific reports · 2017Article
- Are emotion recognition deficits in patients with schizophrenia states or traits? A 6-month follow-up study.Indian journal of psychiatryArticle
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Authors and funding
10 authors.
Yu-Han ChenYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA cheny4@email.chop.edu.
Breannan Stone-HowellYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
J Christopher EdgarYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
Mingxiong HuangYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
Cassandra WoottonYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
Michael A HunterYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
Brett Y LuYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
Joseph R SadekYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
Gregory A MillerYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
José M CañiveYu-Han Chen, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Breannan Stone-Howell, MS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; J. Christopher Edgar, PhD, The Children's Hospital of Philadelphia and University of Pennsylvania, Department of Radiology, Philadelphia; Mingxiong Huang, PhD, University of California, San Diego, Department of Radiology, and San Diego VA Healthcare System, Department of Radiology, San Diego, California; Cassandra Wootton, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico; Michael A. Hunter, BS, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, The University of New Mexico School of Medicine, Department of Psychiatry and Department of Psychology, Albuquerque, New Mexico; Brett Y. Lu, MD, PhD, The University of Hawaii at Manoa, Department of Psychiatry, Honolulu, Hawaii; Joseph R. Sadek, PhD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, New Mexico; Gregory A. Miller, PhD, University of California, Los Angeles, Department of Psychology, Los Angeles, California; José M. Canĩve, MD, New Mexico Raymond G. Murphy VA Healthcare System, Psychiatry Research, Albuquerque, and The University of New Mexico School of Medicine, Department of Psychiatry, Albuquerque, New Mexico, USA.
Funding
Schizophrenia Gating Deficit Mechanisms: Extending the CircuitR01MH065304 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANIVE, JOSE MIGUEL · 2002 to 2013
$3.7MAuditory Cortex Structure and Function in SchizophreniaK08MH085100 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI EDGAR, JAMES CHRISTOPHER · 2010 to 2013
$670kNIMH NIH HHS K08 MH085100NIMH NIH HHS R01 MH065304NIMH NIH HHS R01 MH65304
Abstract
backgroundIncreased temporal and frontal slow-wave delta (1-4 Hz) and theta (4-7 Hz) activities are the most consistent resting-state neural abnormalities reported in schizophrenia. The frontal lobe is associated with negative symptoms and cognitive abilities such as attention, with negative symptoms and impaired attention associated with poor functional capacity.
aimsTo establish whether frontal dysfunction, as indexed by slowing, would be associated with functional impairments.
methodEyes-closed magnetoencephalography data were collected in 41 participants with schizophrenia and 37 healthy controls, and frequency-domain source imaging localised delta and theta activity.
resultsElevated delta and theta activity in right frontal and right temporoparietal regions was observed in the schizophrenia v. CONTROL GROUP: In schizophrenia, right-frontal delta activity was uniquely associated with negative but not positive symptoms. In the full sample, increased right-frontal delta activity predicted poorer attention and functional capacity.
conclusionsOur findings suggest that treatment-associated decreases in slow-wave activity could be accompanied by improved functional outcome and thus better prognosis.
Indexed as
CognitionExecutive FunctionAdultAttentionCase-Control StudiesElectroencephalographyFemaleFrontal LobeHumansMagnetoencephalographyMaleMiddle AgedPrognosisRegression AnalysisSchizophrenia
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