ArticleThe British journal of psychiatry : the journal of mental science2015
Cortical folding and the potential for prognostic neuroimaging in schizophrenia.
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Article in The British journal of psychiatry : the journal of mental science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
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9 citing papers in PubMed, 13 citations in OpenAlex.
- Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes.bioRxiv : the preprint server for biology · 2026Article
- Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting.Schizophrenia (Heidelberg, Germany) · 2022Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A Prospective Longitudinal Investigation of Cortical Thickness and Gyrification in Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illnessJournal of psychiatry & neuroscience : JPN · 2020Article
- Classification of First-Episode Schizophrenia Using Multimodal Brain Features: A Combined Structural and Diffusion Imaging Study.Schizophrenia bulletin · 2019Article
- Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.NeuroImage. Clinical · 2018Article
- Gyrification Connectomes in Unmedicated Patients With Schizophrenia and Following a Short Course of Antipsychotic Drug Treatment.Frontiers in psychiatry · 2018Article
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Authors and funding
6 authors at 5 institutions in 3 countries.
Shuixia GuoShuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
Sarina IwabuchiShuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
Vijender BalainShuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
Jianfeng FengShuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
Peter LiddleShuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.
Lena PalaniyappanShuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada Lena.Palaniyappan@nottingham.ac.uk.
Institute of Mental Health · GBHunan Normal University · CNPenticton Regional Hospital · CAUniversity of Nottingham · GBUniversity of Warwick · GB
Funding
Medical Research Council G0601442Wellcome TrustWellcome Trust WT096002/Z/11
Abstract
In 41 patients with schizophrenia, we used neuroanatomical information derived from structural imaging to identify patients with more severe illness, characterised by high symptom burden, low processing speed, high degree of illness persistence and lower social and occupational functional capacity. Cortical folding, but not thickness or volume, showed a high discriminatory ability in correctly identifying patients with more severe illness.
Indexed as
Magnetic Resonance ImagingNeuroimagingAdultCerebral CortexFemaleHumansLikelihood FunctionsLinear ModelsMaleMiddle AgedSchizophreniaUnited KingdomYoung Adult
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.