ArticlePlant physiology2015
Pseudomonas syringae Effector Avirulence Protein E Localizes to the Host Plasma Membrane and Down-Regulates the Expression of the NONRACE-SPECIFIC DISEASE RESISTANCE1/HARPIN-INDUCED1-LIKE13 Gene Required for Antibacterial Immunity in Arabidopsis.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 64 citations in OpenAlex.
- Pathogen effector tactics to suppress plant endomembrane system.Frontiers in plant science · 2026Review
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- The conserved AvrE family of bacterial effectors: functions and targets during pathogenesis.Trends in microbiology · 2025Review
- Genomic and mutational analysis of Pseudomonas syringae pv. tagetis EB037 pathogenicity on sunflower.BMC microbiology · 2025Article
- A chromosome-level genome assembly provides insights into the local adaptation of Tamarix austromongolica in the Yellow River Basin, China.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Extracellular niche establishment by plant pathogens.Nature reviews. Microbiology · 2024Review
- Defense against phytopathogens relies on efficient antimicrobial protein secretion mediated by the microtubule-binding protein TGNap1.Nature communications · 2023Article
- Bacteria deliver water channels to infect plants.Nature · 2023Article
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- Bacterial pathogens deliver water/solute-permeable channels as a virulence strategy.bioRxiv : the preprint server for biology · 2023Article
- Multitask Approach to Localize Rhizobial Type Three Secretion System Effector Proteins Inside Eukaryotic Cells.Plants (Basel, Switzerland) · 2023Article
- A PDLP-NHL3 complex integrates plasmodesmal immune signaling cascades.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Progress and Challenges in Elucidating the Functional Role of Effectors in the Soybean-Journal of fungi (Basel, Switzerland) · 2022Review
- Evolutionarily conserved bacterial effectors hijack abscisic acid signaling to induce an aqueous environment in the apoplast.Cell host & microbe · 2022Article
- Characterization of Virulence Function of Pseudomonas cichorii Avirulence Protein E1 (AvrE1) during Host Plant Infection.The plant pathology journal · 2021Article
- Synergistically promoting plant health by harnessing synthetic microbial communities and prebiotics.iScience · 2021Review
- Prunus persica plant endogenous peptides PpPep1 and PpPep2 cause PTI-like transcriptome reprogramming in peach and enhance resistance to Xanthomonas arboricola pv. pruni.BMC genomics · 2021Article
- What the Wild Things Do: Mechanisms of Plant Host Manipulation by Bacterial Type III-Secreted Effector Proteins.Microorganisms · 2021Review
- An Arabidopsis downy mildew non-RxLR effector suppresses induced plant cell death to promote biotroph infection.Journal of experimental botany · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Xiu-Fang XinDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Kinya NomuraDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Xinhua DingDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Xujun ChenDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Kun WangDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Kyaw AungDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Francisco UribeDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).ORCID http://orcid.org/0000-0002-3922-6328
Bruce RosaDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Jian YaoDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Jin ChenDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.).
Sheng Yang HeDepartment of Energy Plant Research Laboratory (X.-F.X., K.N., X.D., X.C., K.A., F.U., B.R., J.Y., J.C., S.Y.H.), Department of Plant Biology (X.-F.X.), Department of Biochemistry and Molecular Biology (K.W.), and Howard Hughes Medical Institute (S.Y.H.), Michigan State University, East Lansing, Michigan 48824;State Key Laboratory of Crop Biology, Shandong Provincial Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an, 271018 Shandong, China (X.D.);Key Laboratory of Plant Pathology, Department of Plant Pathology, China Agricultural University, Beijing 100193, China (X.C.);Genome Institute, Washington University, St. Louis, Missouri 63108 (B.R.); andDepartment of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 (J.Y.) hes@msu.edu.ORCID http://orcid.org/0000-0003-1308-498X
Xuzhou Medical College · CNHoward Hughes Medical Institute · USWestern Michigan University · US
Funding
Arabidopsis basal innate immunity to bacterial infectionR01AI060761 · NIAID · MICHIGAN STATE UNIVERSITY · PI HE, SHENG YANG · 2006 to 2010
$1.8MInnate immunity-associated recycling endosome in Arabidopsis and pathogen attackR01GM109928 · NIGMS · MICHIGAN STATE UNIVERSITY · PI HE, SHENG YANG · 2015 to 2018
$1.1MArabidopsis basil immunity to human and plant pathogensR21AI060761 · NIAID · MICHIGAN STATE UNIVERSITY · PI HE, SHENG YANG · 2004 to 2004
$378kManipulation of Host Immunity by Bacterial Effectors in ArabidopsisR56AI060761 · NIAID · MICHIGAN STATE UNIVERSITY · PI HE, SHENG YANG · 2011 to 2011
$374kNIAID NIH HHS AI060761NIAID NIH HHS R01 AI060761NIAID NIH HHS R21 AI060761NIAID NIH HHS R56 AI060761NIGMS NIH HHS GM109928NIGMS NIH HHS R01 GM109928
Abstract
Many bacterial pathogens of plants and animals deliver effector proteins into host cells to promote infection. Elucidation of how pathogen effector proteins function not only is critical for understanding bacterial pathogenesis but also provides a useful tool in discovering the functions of host genes. In this study, we characterized the Pseudomonas syringae pv tomato DC3000 effector protein Avirulence Protein E (AvrE), the founding member of a widely distributed, yet functionally enigmatic, bacterial effector family. We show that AvrE is localized in the plasma membrane (PM) and PM-associated vesicle-like structures in the plant cell. AvrE contains two physically interacting domains, and the amino-terminal portion contains a PM-localization signal. Genome-wide microarray analysis indicates that AvrE, as well as the functionally redundant effector Hypersensitive response and pathogenicity-dependent Outer Protein M1, down-regulates the expression of the NONRACE-SPECIFIC DISEASE RESISTANCE1/HARPIN-INDUCED1-LIKE13 (NHL13) gene in Arabidopsis (Arabidopsis thaliana). Mutational analysis shows that NHL13 is required for plant immunity, as the nhl13 mutant plant displayed enhanced disease susceptibility. Our results defined the action site of one of the most important bacterial virulence proteins in plants and the antibacterial immunity function of the NHL13 gene.
Indexed as
Down-RegulationPlant ImmunityAnti-Bacterial AgentsArabidopsisArabidopsis ProteinsBacterial ProteinsCell MembraneGenes, PlantPlant LeavesPlants, Genetically ModifiedProtein Structure, TertiaryProtein TransportPseudomonas syringaeSequence DeletionVirulenceAnti-Bacterial AgentsArabidopsis ProteinsAvrE protein, Pseudomonas syringaeBacterial Proteins
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