ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Intermingled Klebsiella pneumoniae Populations Between Retail Meats and Human Urinary Tract Infections.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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80 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Antimicrobial resistance in meat and meat products from Asia: An urgent one health challenge- a systematic review and meta-analysis.Poultry science · 2025Pooled it
- Piperine reverses colistin resistance in multidrug resistant Gram-negative pathogens by membrane disruption and ROS damage.Virulence · 2026Article
- Clonal diversity, virulence factors and antibiotic resistance genes ofOne health (Amsterdam, Netherlands) · 2026Article
- Molecular characterization and co-occurrence of ESBL, carbapenemase and mcr-1 genes in Klebsiella pneumoniae from poultry production systems in Pakistan.Molecular biology reports · 2026Article
- Microbiological Quality of Roasted Coffee and Survival Dynamics of Dry-Inoculated Bacteria During Storage.Journal of food science · 2026Article
- Eco-Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron-Rich Mobilomes and Cross-Niche Connectivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Prevalence of extended-spectrum β-lactamase and carbapenemase-producing Klebsiella pneumoniae in humans, animals and the environment in Northwest Amhara, Ethiopia.Scientific reports · 2026Article
- One Health genomic surveillance ofFrontiers in microbiology · 2026Article
- The resistome bridge between livestock and workers: novel frameworks for early detection and monitoring of antimicrobial resistance.Frontiers in public health · 2026Review
- The promising activity of apple cider vinegar on MDR Klebsiella spp. (K. variicola and K. pneumoniae) emerging pathogens in chicken.Veterinary research communications · 2025Article
- A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation.PLoS biology · 2025Article
- Clonal overlap and resistance profiles of multidrug-resistantVeterinary world · 2025Article
- Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian OriginVeterinary sciences · 2025Article
- A genome-wide One Health study of Klebsiella pneumoniae in Norway reveals overlapping populations but few recent transmission events across reservoirs.Genome medicine · 2025Article
- Whole-genome sequencing of Klebsiella pneumoniae MDR circulating in a pediatric hospital setting: a comprehensive genome analysis of isolates from Guayaquil, Ecuador.BMC genomics · 2024Article
- Spice-Induced Metal Contamination and Microbiological Risk Assessment of Instant Noodles Prepared for Human Consumption.Biological trace element research · 2024Article
- Transmission Dynamics and Novel Treatments of High Risk Carbapenem-ResistantPharmaceuticals (Basel, Switzerland) · 2024Review
- Pediatric urinary tract infections caused by poultry-associatedMicrobiology spectrum · 2024Article
- Antimicrobial Resistance in Livestock: A Serious Threat to Public Health.Antibiotics (Basel, Switzerland) · 2024Review
- Idiosyncratic invasion trajectories of human bacterial pathogens facing temperature disturbances in soil microbial communities.Scientific reports · 2024Article
20 more citing papers are in PubMed but not listed here.
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14 authors at 4 institutions in 2 countries.
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Abstract
backgroundKlebsiella pneumoniae is a common colonizer of the gastrointestinal tract of humans, companion animals, and livestock. To better understand potential contributions of foodborne K. pneumoniae to human clinical infections, we compared K. pneumoniae isolates from retail meat products and human clinical specimens to assess their similarity based on antibiotic resistance, genetic relatedness, and virulence.
methodsKlebsiella pneumoniae was isolated from retail meats from Flagstaff grocery stores in 2012 and from urine and blood specimens from Flagstaff Medical Center in 2011-2012. Isolates underwent antibiotic susceptibility testing and whole-genome sequencing. Genetic relatedness of the isolates was assessed using multilocus sequence typing and phylogenetic analyses. Extraintestinal virulence of several closely related meat-source and urine isolates was assessed using a murine sepsis model.
resultsMeat-source isolates were significantly more likely to be multidrug resistant and resistant to tetracycline and gentamicin than clinical isolates. Four sequence types occurred among both meat-source and clinical isolates. Phylogenetic analyses confirmed close relationships among meat-source and clinical isolates. Isolates from both sources showed similar virulence in the mouse sepsis model.
conclusionsMeat-source K. pneumoniae isolates were more likely than clinical isolates to be antibiotic resistant, which could reflect selective pressures from antibiotic use in food-animal production. The close genetic relatedness of meat-source and clinical isolates, coupled with similarities in virulence, suggest that the barriers to transmission between these 2 sources are low. Taken together, our results suggest that retail meat is a potential vehicle for transmitting virulent, antibiotic-resistant K. pneumoniae from food animals to humans.
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