SynthesisEndocrine2015
PET imaging in ectopic Cushing syndrome: a systematic review.
Synthesis in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022Pooled it
- Ectopic ACTH syndrome of different origin-Diagnostic approach and clinical outcome. Experience of one Clinical Centre.PloS one · 2020Trial
- Site-specific performance ofFrontiers in oncology · 2023Article
- ACTH-Independent Cushing's Syndrome Caused by an Ectopic Adrenocortical Adenoma in the Renal Hilum.Diagnostics (Basel, Switzerland) · 2022Article
- Comparison of diagnostic efficacy ofFrontiers in endocrinology · 2022Article
- Head-to-head comparison ofEuropean journal of nuclear medicine and molecular imaging · 2021Article
- PET with Different Radiopharmaceuticals in Neuroendocrine Neoplasms: An Umbrella Review of Published Meta-Analyses.Cancers · 2021Review
- Median 10 years follow-up of patients with covert Cushing's syndrome: a case series.Journal of medical case reports · 2021Article
- Unusual ectopic ACTH syndrome in a patient with orbital neuroendocrine tumor, resulted false-positive outcome of BIPSS:a case report.BMC endocrine disorders · 2020Article
- Functional imaging in ectopic Cushing syndrome.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- Article
- Surgical approach to patients with hypercortisolism.Gland surgery · 2020Review
- Possible pitfalls in the workup of ectopic ACTH secretion illustrated by four rare cases.BMJ case reports · 2019Article
- The Clinical Impact of [Clinical endocrinology · 2019Article
- Small cell lung cancer starting with diabetes mellitus: Two case reports and literature review.World journal of clinical cases · 2019Article
- Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR gene: A case report.Medicine · 2017Article
- Severe Cushing's syndrome due to small cell prostate carcinoma: a case and review of literature.Endocrine connections · 2017Review
- Bronchopulmonary carcinoid with a single lymph node metastasis causing ectopic Cushing's syndrome.Journal of thoracic disease · 2017Article
- Comparison of 68Ga-DOTANOC PET/CT and contrast-enhanced CT in localisation of tumours in ectopic ACTH syndrome.Endocrine connections · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cushing syndrome due to endogenous hypercortisolism may cause significant morbidity and mortality. The source of excess cortisol may be adrenal, pituitary, or ectopic. Ectopic Cushing syndrome is sometimes difficult to localize on conventional imaging like CT and MRI. After performing a multilevel thoracoabdominal imaging with CT, the evidence regarding the use of radiotracers for PET imaging is unclear due to significant molecular and etiological heterogeneity of potential causes of ectopic Cushing's syndrome. In our systematic review of literature, it appears that GalLium-based (Ga68) somatostatin receptor analogs have better sensitivity in diagnosis of bronchial carcinoids causing Cushing syndrome and FDG PET appears superior for small-cell lung cancers and other aggressive tumors. Further large-scale studies are needed to identify the best PET tracer for this condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.