Evidence map›Paper›PMID 26206738›Full record

ArticleJournal of the American Heart Association2015

Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients.

Xiaosong Gu, Liangping Zhao, Jing Zhu, Haibo Gu, Hui Li, Luchen Wang, Weiting Xu, Jianchang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  11. Observational
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xiaosong GuDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
Liangping ZhaoDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
Jing ZhuDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
Haibo GuDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
Hui LiDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
Luchen WangWayne State University School of Medicine, Detroit, MI (L.W.).
Weiting XuDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
Jianchang ChenDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (X.G., L.Z., J.Z., H.G., H.L., W.X., J.C.).
Soochow University · CNSecond Affiliated Hospital of Soochow University · CNWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMimecan plays an important role in endothelial and vascular smooth muscle cell integrity and may be involved the pathology of arterial stiffness. However, the role of mimecan in arterial stiffness in patients with hypertension is not well defined. METHODS AND

resultsA total of 116 hypertension patients and 54 healthy controls were enrolled in the investigation. Hypertensive patients were divided into 2 groups: the with arterial stiffness group (brachial-ankle pulse wave velocity [baPWV] ≥1400 cm/s; n=83) and the without arterial stiffness group (baPWV <1400 cm/s; n=33). A noninvasive measure of vascular stiffness was performed using pulse wave velocity (PWV) measurement of baPWV. Hypertensive patients had higher baPWV, mimecan, and endothelin 1 (ET-1) than healthy controls. The arterial stiffness group had higher mimecan and endothelin 1 (ET-1) and lower ankle-brachial pressure index (ABI) than those without stiffness. In hypertensive patients, mimecan was inversely correlated with ABI (P<0.05) and positively correlated with baPWV, ET-1, and total cholesterol. On multivariable logistic regression analysis, diastolic blood pressure, mimecan, ET-1, and creatinine were independent predictors of arterial stiffness in hypertensive patients (P<0.05).

conclusionsMimecan levels are higher in hypertensive patients than in healthy controls. Increased plasma mimecan levels are independently associated with increased arterial stiffness as assessed by baPWV.

Indexed as

Vascular StiffnessAgedAnkle Brachial IndexArterial PressureBiomarkersCase-Control StudiesChi-Square DistributionCholesterolEndothelin-1FemaleHumansHypertensionIntercellular Signaling Peptides and ProteinsLogistic ModelsMaleMiddle AgedBiomarkersCholesterolEndothelin-1Intercellular Signaling Peptides and ProteinsOGN protein, humanarterial stiffnessET‐1hypertensionmimecan

Identifiers

PMID26206738
PMCPMC4608085
OpenAlexW1906283054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.