ReviewFrontiers in neuroendocrinology2015
Developmental influences on circuits programming susceptibility to obesity.
Review in Frontiers in neuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Timing determines programming of energy homeostasis by maternal PMEnvironmental pollution (Barking, Essex : 1987) · 2024Article
- Single cell tracing of Pomc neurons reveals recruitment of 'Ghost' subtypes with atypical identity in a mouse model of obesity.Nature communications · 2024Article
- Article
- Breast milk leptin concentrations and infant anthropometric indicators in SGA versus non-SGA breastfed infants born at term.Heliyon · 2023Article
- Stimulation of GHRH Neuron Axon Growth by Leptin and Impact of Nutrition during Suckling in Mice.Nutrients · 2023Article
- Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system.Frontiers in endocrinology · 2023Article
- Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids.Metabolites · 2022Article
- AgRP neurons: Regulators of feeding, energy expenditure, and behavior.The FEBS journal · 2022Review
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- FoxO1 Regulates Neuropeptide Y and Pro-opiomelanocortin in the Hypothalamus of Rat Offspring Small for Gestational Age.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Neonatal and Adolescent Adipocytokines as Predictors of Adiposity and Cardiometabolic Risk in Adolescence.Obesity (Silver Spring, Md.) · 2021Article
- POMC neuronal heterogeneity in energy balance and beyond: an integrated view.Nature metabolism · 2021Review
- Long term hypoxia during gestation alters perirenal adipose tissue gene expression in the lamb.Adipocyte · 2020Article
- Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.Cell metabolism · 2019Article
- Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth.Obesity (Silver Spring, Md.) · 2019Article
- Development of homeothermic endothermy is delayed in high-altitude native deer mice (Peromyscus maniculatus).Proceedings. Biological sciences · 2019Article
- Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Feeding circuit development and early-life influences on future feeding behaviour.Nature reviews. Neuroscience · 2018Review
- Associations of maternal and cord blood adipokines with offspring adiposity in Project Viva: is there an interaction with child age?International journal of obesity (2005) · 2018Observational
- Obesity Pathogenesis: An Endocrine Society Scientific Statement.Endocrine reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Suboptimal maternal nutrition exerts lasting impacts on obesity risk in offspring, but the direction of the effect is determined by the timing of exposure. While maternal undernutrition in early pregnancy is associated with increased body mass index, in later pregnancy it can be protective. The importance of the timing of maternal undernutrition is also observed in rodents, however, many of the processes that occur in the last trimester of human gestation are delayed to the postnatal period. Neonatal leptin administration exerts lasting impacts on susceptibility to obesity in rodents. Although leptin can influence the formation of hypothalamic circuits involved in homeostatic control of feeding during the postnatal period, these effects are too late to account for its ability to reverse adverse metabolic programming due to early gestational exposure to maternal undernutrition. This review presents an alternative framework for understanding the effects of neonatal leptin through influences on developing thermoregulatory circuits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.