ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association of lncRNAJournal of genetics · 2021Pooled it
- Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis.Bioscience reports · 2018Pooled it
- Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis.Oncotarget · 2017Pooled it
- The HOTAIR, PRNCR1 and POLR2E polymorphisms are associated with cancer risk: a meta-analysis.Oncotarget · 2017Pooled it
- The Role of lncRNA Polymorphisms in Digestive System Cancers: A Systematic Review and Meta-Analysis.Cancers · 2026Review
- Comprehensive analysis of the lncRNAs-related immune gene signatures and their correlation with immunotherapy in lung adenocarcinoma.British journal of cancer · 2023Article
- PRNCR1: a long non-coding RNA with a pivotal oncogenic role in cancer.Human genetics · 2022Review
- Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS.Genes · 2021Review
- Evaluating the Possible Association between PD-1 (Rs11568821, Rs2227981, Rs2227982) and PD-L1 (Rs4143815, Rs2890658) Polymorphisms and Susceptibility to Breast Cancer in a Sample of Southeast Iranian Women.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview.International journal of molecular sciences · 2020Review
- Long Noncoding RNAs, New Critical Regulators in Cancer Immunity.Frontiers in oncology · 2020Review
- Computational Prediction of Probable Single Nucleotide Polymorphism-Cancer Relationships.Cancer informatics · 2020Article
- Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview.Cell & bioscience · 2020Review
- Correlations between Genetic Polymorphisms in Long Non-Coding RNAInternational journal of molecular sciences · 2019Article
- Association between polymorphisms in PRNCR1 and risk of colorectal cancer in the Saudi population.PloS one · 2019Article
- Single nucleotide polymorphisms and cancer susceptibility.Oncotarget · 2017Review
- Association between genetic polymorphisms of long non-coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population.Molecular and clinical oncology · 2017Article
- Long non-coding RNA polymorphisms in 6p21.1 are associated with atrophic gastritis risk and gastric cancer prognosis.Oncotarget · 2017Article
- Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer.International journal of molecular sciences · 2017Review
- Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population.Journal of Cancer · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A long ncRNA (lncRNA) prostate cancer non-coding RNA 1 (PRNCR1) in the 8q24 has been reported to be upregulated in prostate cancer with a function of activating androgen receptor (AR). AR plays a key role in the gender disparity, cell migration, and invasion of gastric cancer (GC). We hypothesized that single nucleotide polymorphisms (SNPs) in the lncRNA PRNCR1 may be related to the risk of GC. We conducted a case-control study to investigate the association between SNPs in the lncRNA PRNCR1 and the risk of GC. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used to determine the genotypes of 613 subjects including 219 cases with GC and 394 controls. We found that patients with the rs13252298AG genotype displayed a 1.50-fold increased risk of GC (AG vs. AA, 95 % confidence interval (CI) = 1.05-2.12, p = 0.02). Interestingly, the rs7007694CT and CC and the rs1456315GG genotypes displayed a decreased risk of GC (rs7007694CT vs. TT, odds ratio (OR) = 0.68, 95 % CI = 0.48-0.97, p = 0.03; rs7007694CC vs. TT, OR = 0.36, 95 % CI = 0.13-0.97, p = 0.04; rs1456315GG vs. AA, OR = 0.30, 95 % CI = 0.13-0.70, p = 0.004, respectively). Our results suggest that SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of GC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.